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Journal articles

Intracellular offspring released from SFB filaments are flagellated

Iris Nkamba ^{1, 2} Céline Mulet ³ Gyanendra Dubey ³ Olivier Gorgette ⁴ Aurélie Couesnon ¹ Audrey Salles ⁵ Maryse Moya-Nilges ⁴ Vincent Jung ⁶ Valérie Gaboriau-Routhiau ^{1, 7} Ida Chiara Guerrera ⁶ Tatsuichiro Shima ⁸ yoshinori Umesaki ⁸ Giulia S Nigro ³ Jacomina Krijnse-Locker ⁴ Marion Bérard ⁹ Nadine Cerf-Bensussan ^{1, 2} Philippe Sansonetti ^{3, 10} Pamela Schnupf ^{1, 2, 11}

1 Equipe Inserm U1163 - Laboratory of Intestinal Immunity

Imagine - U1163 - Imagine - Institut des maladies génétiques (IHU)

2 UPC Faculté SHS - Université Paris Cité - Faculté des Sciences humaines et sociales [Sociétés et Humanités]

3 Pathogénie microbienne moléculaire

4 UTechS UBI - Plateforme BioImagerie Ultrastructurale – Ultrastructural BioImaging Platform

5 UTechS PBI - BioImagerie Photonique – Photonic BioImaging

6 PPN - 3P5 - Plateforme Protéomique Necker [SFR Necker]

SFR Necker - UMS 3633 / US24 - Structure Fédérative de Recherche Necker

7 MICALIS - MICrobiologie de l'ALImentation au Service de la Santé

8 Yakult Central institute [Tokyo]

9 Animalerie centrale (Plate-forme)

10 Chaire Microbiologie et Maladies infectieuses

11 Laboratoire Interaction Hôte-Microbiote [Institut Necker Enfants Malades, Paris]

INEM - UM 111 (UMR 8253 / U1151) - Institut Necker Enfants-Malades

Abstract : The gut commensal segmented filamentous bacterium (SFB) attaches to the ileal epithelium and potently stimulates the host immune system. Using transmission electron microscopy (TEM), we show that mouse and rat SFB are flagellated above the concave tip at the unicellular intracellular offspring (IO) stage and that flagellation occurs prior to full IO differentiation and release of IOs from SFB filaments. This finding adds a missing link to the SFB life cycle.

Keywords : Bacterial host response Bacterial physiology Bacterial development

Document type :

Journal articles

Domain :

Life Sciences [q-bio]

Complete list of metadata

https://hal-pasteur.archives-ouvertes.fr/pasteur-02557372
Contributor : Audrey Salles Connect in order to contact the contributor
Submitted on : Monday, June 15, 2020 - 11:19:33 PM
Last modification on : Thursday, May 12, 2022 - 9:04:07 AM