Clinical characteristics of pediatric hidradenitis suppurativa: a cross-sectional multicenter study of 140 patients

Peter Theut Riis (1, 2) , Ditte Marie Saunte (1, 2) , Viktoria Sigsgaard (1, 2) , Axel Patrice Villani (3, 4) , Philippe Guillem (3) , José Pascual (5, 6) , Naomi N Kappe (7) , Annika M J D Vanlaerhoven (7) , Hessel van Der Zee (7) , Errol P Prens (7) , Moetaz El-Domyati (8) , Hossam Abdel-Wahab (8) , Nayera Moftah (9) , Rania Abdelghani (9, 10) , Eugenia Agut-Busquet (11, 12) , Jorge Romaní (11, 13) , Carol Hlela (14, 15) , Lerinza van den Worm (15, 14) , Vincenzo Bettoli (16) , Giada Calamo (16) , Mehmet Ali Gürer (17) , Burcu Beksaç (17) , Lukasz Matusiak (18) , Amelia Glowaczewska (18) , Jacek Szepietowski (18) , Lennart Emtestam (19) , Jan Lapins (19) , Hassan Riad Kottb (20) , Mohammad Fatani (21) , Lisa Weibel (22, 23) , Martin Theiler (22, 23) , Maïa Delage-Toriel (24) , Thi Thanh Hong Lam (24) , Aude Nassif (24) , Pierre-Andre Becherel (25) , Mateja Dolenc-Voljc (26, 27) , Nejib Doss (28) , Dorra Bouazzi (1, 2) , Farida Benhadou (29, 30, 31) , Véronique del Marmol (30, 31) , Gregor Jemec (1, 2)

1 Zealand University Hospital [Roskilde, Denmark]
2 UCPH - University of Copenhagen = Københavns Universitet
3 Service de dermatologie [HCL Lyon]
4 Clinique du Val d'Ouest
5 Hospital Universitario de Alicante
6 ISABIAL-FISABIO - Instituto de Investigación Sanitaria y Biomédica de Alicante
7 Erasmus MC - Erasmus University Medical Center [Rotterdam]
8 Minia University
9 Al-Azhar University [Cairo, Egypt]
10 AFCM - Armed Forces College of Medicine [Cairo, Egypt]
11 UAB - Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona
12 Hospital de la Santa Creu i Sant Pau
13 Hospital Universitari Parc Taulí of Sabadell, Barcelona
14 University of Cape Town
15 Red Cross Children's Hospital [Cape Town, South Africa]
16 Azienda Ospedaliero Universitaria di Ferrara [Cona, Italy]
17 Gazi University
18 Wrocław Medical University
19 Karolinska Institutet [Stockholm]
20 Hamad medical corporation
21 Hera General Hospital [Makkah, Saudi Arabia]
22 University Children’s Hospital Zurich
23 University hospital of Zurich [Zurich]
24 CMIP - Centre Médical de l'Institut Pasteur
25 Hôpital privé d’Antony
26 University of Ljubljana
27 UMCL - University Medical Centre Ljubljana [Ljubljana, Slovenia]
28 Department of Dermatology
29 Hôpital militaire de Tunis
30 ULB - Hôpital Erasme [Bruxelles]
31 ULB - Université libre de Bruxelles

Hidradenitis suppurativa (HS) rarely affects pediatric patients. The literature on pediatric HS patients is scarce. This is a cross-sectional study based on case note review or interviews and clinical examination of 140 pediatric patients undergoing secondary or tertiary level care. Patients were predominantly female (75.5%, n = 105) with a median age of 16. 39% reported 1st-degree relative with HS. Median BMI percentile was 88, and 11% were smokers (n = 15). Median modified Sartorius score was 8.5. Notable comorbidities found were acne (32.8%, n = 45), hirsutism (19.3%, n = 27), and pilonidal cysts (16.4%, n = 23). Resorcinol (n = 27) and clindamycin (n = 25) were the most frequently used topical treatments. Patients were treated with tetracycline (n = 32), or oral clindamycin and rifampicin in combination (n = 29). Surgical excision was performed in 18 patients, deroofing in five and incision in seven patients. Obesity seemed to be prominent in the pediatric population and correlated to parent BMI, suggesting a potential for preventive measures for the family. Disease management appeared to be similar to that of adult HS, bearing in mind that the younger the patient, the milder the disease in majority of cases.

Mots clés: Acne inversa; Children; Hidradenitis suppurativa; Pediatric

Domaines: Sciences du Vivant [q-bio]; Médecine humaine et pathologie; Dermatologie

Peter Theut Riis, Ditte Marie Saunte, Viktoria Sigsgaard, Axel Patrice Villani, Philippe Guillem, et al.. Clinical characteristics of pediatric hidradenitis suppurativa: a cross-sectional multicenter study of 140 patients. Archives of Dermatological Research, 2020, 1, ⟨10.1007/s00403-020-02053-6⟩. ⟨pasteur-02547303⟩