Human Exposure to Hantaviruses Associated with Rodents of the Murinae Subfamily, Madagascar

Harinirina Aina Rabemananjara (1) , Vololoniaina Raharinosy (1) , Ravo Michèle Razafimahefa (1) , Jean Pierre Ravalohery (1) , Jean Théophile Rafisandratantsoa (1) , Soa Fy Andriamandimby (1) , Minoarisoa Rajerison (1) , Soanandrasana Rahelinirina (1) , Aina Harimanana (1) , Judickaelle Irinantenaina (1) , Marie-Marie Olive (1) , Christophe Rogier (1, 2) , Noël Tordo (3, 4) , Rainer Ulrich (5, 6) , Jean-Marc Reynes (4) , Stéphane Petres (4) , Jean-Michel Heraud (1) , Sandra Telfer (7) , Claudia Filippone (1)

1 Institut Pasteur de Madagascar
2 Service de Santé des Armées
3 Institut Pasteur de Guinée
4 IP - Institut Pasteur [Paris]
5 FLI - Friedrich-Loeffler-Institut
6 DZIF - German Centre for Infection Research
7 University of Aberdeen

We conducted a national human serologic study of a hantavirus detected in Madagascar rodents using a commercial kit and a new ELISA targeting the virus. Our results suggest a conservative estimate of 2.7% (46/1,680) IgG seroprevalence. A second single-district study using the new ELISA revealed a higher prevalence (7.2%; 10/139).

Keywords: Madagascar; Murinae; hantavirus; human population; rodents; seroprevalence; viruses; zoonoses

Domains: Life Sciences [q-bio]; Microbiology and Parasitology; Virology; Environmental Sciences; Biodiversity and Ecology; Environmental Sciences; Environmental and Society; Life Sciences [q-bio]; Human health and pathology; Infectious diseases

Harinirina Aina Rabemananjara, Vololoniaina Raharinosy, Ravo Michèle Razafimahefa, Jean Pierre Ravalohery, Jean Théophile Rafisandratantsoa, et al.. Human Exposure to Hantaviruses Associated with Rodents of the Murinae Subfamily, Madagascar. Emerging Infectious Diseases, 2020, 26 (3), pp.587-590. ⟨10.3201/eid2603.190320⟩. ⟨pasteur-02545946⟩