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Helicobacter bilis-Associated Suppurative Cholangitis in a Patient with X-Linked Agammaglobulinemia

Abstract : Helicobacter bilis is a commensal bacterium causing chronic hepatitis and colitis in mice. In humans, enterohepatic Helicobacter spp. are associated with chronic hepatobiliary diseases. Purpose : We aimed at understanding the microbial etiology in a patient with X-linked agammaglobulinemia presenting with suppurative cholangitis. Methods : 16S rDNA PCR directly performed on a liver biopsy retrieved DNA of H. bilis. Results : Clinical outcome resulted in the normalization of clinical and biological parameters under antibiotic treatment by a combination of ceftriaxone, metronidazole, and doxycyclin followed by a 2-week treatment with moxifloxacin and a 2-month treatment with azithromycin. Conclusion : In conclusion, these data suggest a specific clinical and microbiological approach in patients with humoral deficiency in order to detect H. bilis hepatobiliary diseases.
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Submitted on : Wednesday, January 22, 2020 - 4:44:41 PM
Last modification on : Wednesday, August 19, 2020 - 11:18:00 AM

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Nicolas Degand, Justine Dautremer, Benoit Pilmis, Agnès Ferroni, Fanny Lanternier, et al.. Helicobacter bilis-Associated Suppurative Cholangitis in a Patient with X-Linked Agammaglobulinemia. Journal of Clinical Immunology, Springer Verlag, 2017, 37 (7), pp.727-731. ⟨10.1007/s10875-017-0437-z⟩. ⟨pasteur-02449154⟩

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