Decoding glycan recognition by bacterial toxins

Sandrine Bourdoulous (1) , Emmanuel Lemichez (2)

1 IC UM3 (UMR 8104 / U1016) - Institut Cochin
2 Toxines bactériennes dans la relation hôtes-pathogènes

Functional and structural studies highlight the remarkable evolution and features of the typhoid toxin from Salmonella Typhi. This reveals that attachment of the toxin to specific N-glycan chains accounts for its tropism for selected human tissues.

Mots clés: Bacterial pathogenesis; Bacterial toxins; Glycobiology; Glycosylation

Domaines: Sciences du Vivant [q-bio]; Microbiologie et Parasitologie; Bactériologie; Biologie cellulaire; Organisation et fonctions cellulaires [q-bio.SC]; Interactions cellulaires [q-bio.CB]

Sandrine Bourdoulous, Emmanuel Lemichez. Decoding glycan recognition by bacterial toxins. Nature Microbiology, 2018, 3 (2), pp.124-126. ⟨10.1038/s41564-018-0107-9⟩. ⟨pasteur-02448664⟩