Decoding glycan recognition by bacterial toxins

Sandrine Bourdoulous (1) , Emmanuel Lemichez (2)

1 IC UM3 (UMR 8104 / U1016) - Institut Cochin
2 Toxines bactériennes dans la relation hôtes-pathogènes

Functional and structural studies highlight the remarkable evolution and features of the typhoid toxin from Salmonella Typhi. This reveals that attachment of the toxin to specific N-glycan chains accounts for its tropism for selected human tissues.

Keywords: Bacterial pathogenesis; Bacterial toxins; Glycobiology; Glycosylation

Domains: Life Sciences [q-bio]; Life Sciences [q-bio]; Microbiology and Parasitology; Life Sciences [q-bio]; Microbiology and Parasitology; Bacteriology; Life Sciences [q-bio]; Cellular Biology; Life Sciences [q-bio]; Cellular Biology; Subcellular Processes [q-bio.SC]; Life Sciences [q-bio]; Cellular Biology; Cell Behavior [q-bio.CB]

Sandrine Bourdoulous, Emmanuel Lemichez. Decoding glycan recognition by bacterial toxins. Nature Microbiology, 2018, 3 (2), pp.124-126. ⟨10.1038/s41564-018-0107-9⟩. ⟨pasteur-02448664⟩