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Species-specific impact of the autophagy machinery on Chikungunya virus infection

Abstract : Chikungunya virus (CHIKV) is a recently re-emerged arbovirus that triggers autophagy. Here, we show that CHIKV interacts with components of the autophagy machinery during its replication cycle, inducing a cytoprotective effect. The autophagy receptor p62 protects cells from death by binding ubiquitinated capsid and targeting it to autophagolysosomes. By contrast, the human autophagy receptor NDP52-but not its mouse orthologue-interacts with the non-structural protein nsP2, thereby promoting viral replication. These results highlight the distinct roles of p62 and NDP52 in viral infection, and identify NDP52 as a cellular factor that accounts for CHIKV species specificity.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02447347
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Submitted on : Tuesday, January 21, 2020 - 3:22:18 PM
Last modification on : Friday, May 29, 2020 - 5:40:22 AM

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Delphine Judith, Serge Mostowy, Mehdi Bouraï, Nicolas Gangneux, Mickaël Lelek, et al.. Species-specific impact of the autophagy machinery on Chikungunya virus infection. EMBO Reports, EMBO Press, 2013, 14 (6), pp.534 - 544. ⟨10.1038/embor.2013.51⟩. ⟨pasteur-02447347⟩

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