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Transcription activation of a UV-inducible Clostridium perfringens bacteriocin gene by a novel σ factor

Abstract : Expression of the plasmid-encoded Clostridium perfringens gene for bacteriocin BCN5 was shown to depend in vivo and in vitro on the activity of UviA protein. UviA, also plasmid-encoded, proved to be an RNA polymerase sigma factor and was also partly autoregulatory. The uviA gene has two promoters; one provided a UviA-independent, basal level of gene expression while the stronger, UviA-dependent promoter was only utilized after the cell experienced DNA damage. As a result, BCN5 synthesis is induced by treatment with UV light or mitomycin C. UviA is related to a special class of sigma factors found to date only in Clostridium species and responsible for activating transcription of toxin genes in Clostridium difficile, Clostridium tetani, and Clostridium botulinum.
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Submitted on : Friday, January 17, 2020 - 3:52:59 PM
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Bruno Dupuy, Nagraj Mani, Seiichi Katayama, Abraham Sonenshein. Transcription activation of a UV-inducible Clostridium perfringens bacteriocin gene by a novel σ factor. Molecular Microbiology, Wiley, 2005, 55 (4), pp.1196-1206. ⟨10.1111/j.1365-2958.2004.04456.x⟩. ⟨pasteur-02444099⟩

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