Skip to Main content Skip to Navigation
New interface
Journal articles

The influence of space and time on the establishment of B cell identity

Abstract : During embryonic development multiple waves of hematopoietic progenitors with distinct lineage potential are differentially regulated in time and space. Consistent with this view, some specialized lymphocytes emerge during a limited time-window in embryogenesis and migrate to the tissues where they contribute to organogenesis and to tissue homeostasis. These cells are not constantly produced by bone marrow derived hematopoietic stem cells but are maintained in tissues and self-renew throughout life. These particular cell subsets are produced from lymphoid restricted progenitors only found in the first days of fetal liver hematopoietic activity. Growing evidence of the heterogeneity and layered organization of the hematopoietic system is leading to a common view that some lymphocyte subsets are functionally different because they follow distinct developmental programs and emerge from distinct waves of lymphoid progenitors. However, understanding the influence of developmental origin and the relative contribution of local microenvironment on the development of these specialized lymphocyte subsets needs further analysis. In this review, we discuss how different pathways followed by developing B cells during ontogeny may contribute to the diverse functions.
Document type :
Journal articles
Complete list of metadata

Cited literature [89 references]  Display  Hide  Download
Contributor : Marie-Christine Vougny Connect in order to contact the contributor
Submitted on : Friday, November 15, 2019 - 2:39:15 PM
Last modification on : Thursday, April 7, 2022 - 10:10:38 AM


Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License



Ramy Elsaid, Junjie Yang, Ana Cumano. The influence of space and time on the establishment of B cell identity. Biomedical journal, 2019, Review Article: Special Edition, 42 (4), pp.209-217. ⟨10.1016/⟩. ⟨pasteur-02365637⟩



Record views


Files downloads