Recent findings related to immune responses against leptospirosis and novel strategies to prevent infection - Archive ouverte HAL Access content directly
Journal Articles Microbes and Infection Year : 2018

Recent findings related to immune responses against leptospirosis and novel strategies to prevent infection

(1) , (1)
1

Abstract

What are the new approaches and emerging ideas to prevent leptospirosis, a neglected bacterial re-emerging zoonotic disease? How do Leptospira interrogans escape the host defenses? We aim here to review and discuss the most recent literature that provides some answers to these questions, in particular data related to a better understanding of adaptive and innate immunity towards leptospires, and design of vaccines. This is an opinion paper, not a comprehensive review. We will try to highlight the new strategies and technologies boosting the search for drugs and vaccines. We will also address the bottlenecks and difficulties impairing the search for efficient vaccines and the many gaps in our knowledge of immunity against leptospirosis. Finally, we aim to delineate how Leptospira spp. escape the innate immune responses of Toll-Like receptors (TLR) and Nod-Like receptors (NLR). The rational use of TLR and NLR agonists as adjuvants could be key to design future vaccines against pathogenic leptospires.
Fichier principal
Vignette du fichier
1-s2.0-S1286457918300455-main-2.pdf (890.05 Ko) Télécharger le fichier
Origin : Explicit agreement for this submission
Loading...

Dates and versions

pasteur-02337027 , version 1 (29-10-2019)

Licence

Attribution - NonCommercial - NoDerivatives - CC BY 4.0

Identifiers

Cite

Frédérique Vernel-Pauillac, Catherine Werts. Recent findings related to immune responses against leptospirosis and novel strategies to prevent infection. Microbes and Infection, 2018, 20 (9-10), pp.578-588. ⟨10.1016/j.micinf.2018.02.001⟩. ⟨pasteur-02337027⟩

Collections

PASTEUR
35 View
678 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More