Skip to Main content Skip to Navigation
New interface
Journal articles

The prion-like spreading of α-synuclein: From in vitro to in vivo models of Parkinson’s disease

Jessica Vargas 1 Clara Grudina 1 Chiara Zurzolo 1, * 
* Corresponding author
Abstract : Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. PD is characterized by the loss of dopaminergic neurons, primarily in brain regions that control motor functions, thereby leading to motor impairments in the patients. Pathological aggregated forms of the synaptic protein, α-synuclein (α-syn), are involved in the generation and progression of PD. In PD brains, α-syn accumulates inside neurons and propagates from cell-to-cell in a prion-like manner. In this review, we discuss the in vitro and in vivo models used to study the prion-like properties of α-syn and related findings. In particular, we focus on the different mechanisms of α-syn spreading, which could be relevant for the development of alternative therapeutic approaches for PD treatment.
Document type :
Journal articles
Complete list of metadata

https://hal-pasteur.archives-ouvertes.fr/pasteur-02263600
Contributor : Accord Elsevier CCSD Connect in order to contact the contributor
Submitted on : Thursday, October 21, 2021 - 8:15:57 PM
Last modification on : Thursday, April 7, 2022 - 10:10:35 AM
Long-term archiving on: : Saturday, January 22, 2022 - 8:48:06 PM

File

S1568163718302617.pdf
Files produced by the author(s)

Licence


Distributed under a Creative Commons Attribution - NonCommercial 4.0 International License

Identifiers

Collections

Citation

Jessica Vargas, Clara Grudina, Chiara Zurzolo. The prion-like spreading of α-synuclein: From in vitro to in vivo models of Parkinson’s disease. Ageing Research Reviews - ARR, 2019, 50, pp.89-101. ⟨10.1016/j.arr.2019.01.012⟩. ⟨pasteur-02263600⟩

Share

Metrics

Record views

28

Files downloads

110