Fatal Invasive Infection with Fungemia Due to Microascus cirrosus after Heart and Lung Transplantation in a Patient with Cystic Fibrosis

Charline Miossec (1) , Florent Morio (1, 2) , Thierry Lepoivre (1) , Patrice Le Pape (1, 2) , Dea Garcia-Hermoso (3) , Françoise Gay-Andrieu (1, 2) , Alain Haloun (1) , Michele Treilhaud (1) , François Leclair (1) , Michel Miegeville (1, 2)

1 CHU Nantes - Centre hospitalier universitaire de Nantes
2 UN - Université de Nantes
3 CNRMA - Centre National de Référence des Mycoses invasives et antifongiques - Mycologie moléculaire

Scopulariopsis species are rarely but increasingly recognized as opportunistic pathogens in immunocompromised patients. We report on a patient suffering from cystic fibrosis who developed disseminated fungal infection due to a rare Scopulariopsis species, Microascus cirrosus, after heart and lung transplantation. Despite antifungal combination therapy with voriconazole and caspofungin, the patient died 4 weeks after transplantation. Diagnostic difficulties and optimal management of disseminated Scopulariopsis/Microascus infections are discussed.

Domains: Mycology

Charline Miossec, Florent Morio, Thierry Lepoivre, Patrice Le Pape, Dea Garcia-Hermoso, et al.. Fatal Invasive Infection with Fungemia Due to Microascus cirrosus after Heart and Lung Transplantation in a Patient with Cystic Fibrosis. Journal of Clinical Microbiology, 2011, 49 (7), pp.2743-2747. ⟨10.1128/JCM.00127-11⟩. ⟨pasteur-02262481⟩