Experimental murine model of disseminated infection by Saksenaea vasiformis : successful treatment with posaconazole

Valentina Salas (1) , F Javier Pastor (1) , Enrique Calvo (1) , Dea Sutton (2) , Dea Garcia-Hermoso (3) , Emilio Mayayo (1) , Françoise Dromer (3) , Anette Fothergill (2) , Eduardo Alvarez (1) , Josep Guarro (1)

1 Universitat Rovira i Virgili
2 UTSA - The University of Texas at San Antonio
3 CNRMA - Centre National de Référence des Mycoses invasives et antifongiques - Mycologie moléculaire

We have determined the in vitro activity of amphotericin B (AMB) and posaconazole (PSC) against Saksenaea vasiformis using broth microdilution and disk diffusion methods and determined the minimal fungicidal concentration (MFC). PSC was found to have the greatest in vitro activity in all cases and was the most efficacious in prolonging survival and reducing the fungal load in an immunocompetent murine model of disseminated infection caused by four strains of the fungus.

Keywords: murine model; posaconazole; S. vasiformis

Domains: Life Sciences [q-bio]; Microbiology and Parasitology; Mycology

Valentina Salas, F Javier Pastor, Enrique Calvo, Dea Sutton, Dea Garcia-Hermoso, et al.. Experimental murine model of disseminated infection by Saksenaea vasiformis : successful treatment with posaconazole. Medical Mycology, 2012, 50 (7), pp.710-715. ⟨10.3109/13693786.2012.673137⟩. ⟨pasteur-02262343⟩