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Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study

Carolyne M Ndila 1 Sophie Uyoga 1 Alexander W Macharia 1 Gideon Nyutu 1 Norbert Peshu 1 John Ojal 1 Mohammed Shebe 1 Kennedy O Awuondo 1 Neema Mturi 1 Benjamin Tsofa 1 Nuno Sepúlveda 2 Taane G Clark 2 Gavin Band 1 Geraldine Clarke 1 Kate Rowlands 1 Christina Hubbart 1 Anna Jeffreys 1 Silvia Kariuki 3 Kevin Marsh Margaret Mackinnon Kathryn Maitland Dominic P Kwiatkowski 4 Kirk A Rockett 1 Thomas N Williams 5 Malariagen Consortium
1 The Wellcome Trust Centre for Human Genetics [Oxford]
2 LSHTM - London School of Hygiene and Tropical Medicine
3 The Wellcome Trust Sanger Institute [Cambridge]
4 University of Oxford [Oxford]
5 St Mary's Hospital, Imperial College
Abstract : Background Human genetic factors are important determinants of malaria risk. We investigated associations between multiple candidate polymorphisms-many related to the structure or function of red blood cells-and risk for severe Plasmodium falciparum malaria and its specific phenotypes, including cerebral malaria, severe malaria anaemia, and respiratory distress.
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Carolyne M Ndila, Sophie Uyoga, Alexander W Macharia, Gideon Nyutu, Norbert Peshu, et al.. Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study. The Lancet Haematology, Elsevier, 2018, 5 (8), pp.e333-e345. ⟨10.1016/S2352-3026(18)30107-8⟩. ⟨pasteur-02084676⟩

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