Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study

Carolyne M Ndila (1) , Sophie Uyoga (1) , Alexander W Macharia (1) , Gideon Nyutu (1) , Norbert Peshu (1) , John Ojal (1) , Mohammed Shebe (1) , Kennedy O Awuondo (1) , Neema Mturi (1) , Benjamin Tsofa (1) , Nuno Sepúlveda (2) , Taane G Clark (2) , Gavin Band (1) , Geraldine Clarke (1) , Kate Rowlands (1) , Christina Hubbart (1) , Anna Jeffreys (1) , Silvia Kariuki (3) , Kevin Marsh , Margaret Mackinnon , Kathryn Maitland , Dominic P Kwiatkowski (4) , Kirk A Rockett (1) , Thomas N Williams (5) , Malariagen Consortium

1 The Wellcome Trust Centre for Human Genetics [Oxford]
2 LSHTM - London School of Hygiene and Tropical Medicine
3 The Wellcome Trust Sanger Institute [Cambridge]
4 University of Oxford
5 St Mary's Hospital, Imperial College

Background Human genetic factors are important determinants of malaria risk. We investigated associations between multiple candidate polymorphisms-many related to the structure or function of red blood cells-and risk for severe Plasmodium falciparum malaria and its specific phenotypes, including cerebral malaria, severe malaria anaemia, and respiratory distress.

Domains: Life Sciences [q-bio]; Quantitative Methods [q-bio.QM]; Life Sciences [q-bio]; Genetics; Human genetics; Life Sciences [q-bio]; Microbiology and Parasitology; Parasitology; Life Sciences [q-bio]; Santé publique et épidémiologie

Carolyne M Ndila, Sophie Uyoga, Alexander W Macharia, Gideon Nyutu, Norbert Peshu, et al.. Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study. The Lancet Haematology, 2018, 5 (8), pp.e333-e345. ⟨10.1016/S2352-3026(18)30107-8⟩. ⟨pasteur-02084676⟩