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High predicted strain coverage by the multicomponent meningococcal serogroup B vaccine (4CMenB) in Poland.

Abstract : Neisseria meningitidis of serogroup B (MenB) is currently responsible for more than 70% of cases of invasive meningococcal disease (IMD) in Poland and Europe as a whole. The aim of this study was to estimate strain coverage of a multicomponent meningococcal serogroup B vaccine (4CMenB) in Poland; the meningococcal antigen typing system (MATS) was used to test a panel of 196 invasive MenB strains isolated in Poland in 2010 and 2011. The strains were also characterized by MLST and sequencing of porA, factor H-binding protein (fHbp), Neisserial heparin-binding antigen (nhba) and Neisserial adhesin A (nadA) genes. MATS and molecular data were analyzed independently and in combination. The MATS results predicted that 83.7% (95% CI: 78.6-91.0%) of isolates would be covered by the 4CMenB vaccine; 59.2% by one vaccine antigen, 19.9% by two and 4.6% by three antigens. Coverage by each antigen was as follows: fHbp 73.0% (95% CI: 68.9-77.5%), NHBA 28.6% (95% CI: 13.3-47.4%), NadA 1.0% (95% CI: 1.0-2.0%) and PorA 10.2%. Molecular analysis revealed that the most frequent clonal complexes (ccs) were cc32 (33.2%), cc18 (17.9%) and cc41/44 (15.8%) with estimated coverage of 98.5%, 88.6% and 93.5%, respectively. Consistent with findings for other European countries, our study predicts high coverage by the 4CMenB vaccine in Poland.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02060307
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Submitted on : Thursday, March 7, 2019 - 12:14:17 PM
Last modification on : Monday, January 13, 2020 - 5:08:15 PM

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Izabela Waśko, Eva Hong, Rosita de Paola, Maria Stella, Monica Moschioni, et al.. High predicted strain coverage by the multicomponent meningococcal serogroup B vaccine (4CMenB) in Poland.. Vaccine, Elsevier, 2016, 34 (4), pp.510-515. ⟨10.1016/j.vaccine.2015.11.070⟩. ⟨pasteur-02060307⟩

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