Neisseria meningitidis Serogroup X in Sub-Saharan Africa.

Alain Agnememel (1) , Eva Hong (1) , Dario Giorgini (1) , Viginia Nuñez-Samudio (1) , Ala-Eddine Deghmane (1) , Muhamed-Kheir Taha (1)

1 Institut Pasteur [Paris]

The epidemiology of meningococcal disease varies by geography and time. Whole-genome sequencing of Neisseria meningitidis serogroup X isolates from sub-Saharan Africa and Europe showed that serogroup X emergence in sub-Saharan Africa resulted from expansion of particular variants within clonal complex 181. Virulence of these isolates in experimental mouse models was high.

Keywords: Neisseria meningitidis; bacteria; emergence; meningitis; meningococci; serogroup X; sub-Saharan Africa; virulence; whole-genome sequencing

Domains: Life Sciences [q-bio]; Santé publique et épidémiologie; Life Sciences [q-bio]; Human health and pathology; Infectious diseases; Life Sciences [q-bio]; Microbiology and Parasitology; Bacteriology

Alain Agnememel, Eva Hong, Dario Giorgini, Viginia Nuñez-Samudio, Ala-Eddine Deghmane, et al.. Neisseria meningitidis Serogroup X in Sub-Saharan Africa.. Emerging Infectious Diseases, 2016, 22 (4), pp.698-702. ⟨10.3201/eid2204.150653⟩. ⟨pasteur-02060243⟩