From dynamic chromatin architecture to DNA damage repair and back

Emmanuelle Fabre (1, 2) , Christophe Zimmer (3, 4)

1 Pathologie cellulaire : aspects moléculaires et viraux / Pathologie et Virologie Moléculaire
2 USPC - Université Sorbonne Paris Cité
3 Imagerie et Modélisation - Imaging and Modeling
4 C3BI - Centre de Bioinformatique, Biostatistique et Biologie Intégrative

Maintaining the integrity of the genome in the face of DNA damage is crucial to ensure the survival of the cell and normal development. DNA lesions and repair occur in the context of the chromatin fiber, whose 3D organization and movements in the restricted volume of the nucleus are under intense scrutiny. Here, we highlight work from our and other labs that addresses how the dynamic organization of the chromatin fiber affects the repair of damaged DNA and how, conversely, DNA damage and repair affect the structure and dynamics of chromatin in the budding yeast nucleus.

Keywords: chromatin structure; Polymer simulations; homologous recombination; nuclear organization; Chromatin; Chromosome; DNA repair; chromatin dynamics

Domains: Life Sciences [q-bio]; Cellular Biology; Subcellular Processes [q-bio.SC]; Life Sciences [q-bio]; Biochemistry, Molecular Biology; Molecular biology

Emmanuelle Fabre, Christophe Zimmer. From dynamic chromatin architecture to DNA damage repair and back. Nucleus, 2018, 9 (1), pp.161-170. ⟨10.1080/19491034.2017.1419847⟩. ⟨pasteur-02060127⟩