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3Imagerie et Modélisation - Imaging and Modeling (Département Biologie computationnelle,
Département de Biologie cellulaire et Infection,
25-28, rue du docteur Roux, 75724 Paris Cedex 15 - France)
Abstract : Maintaining the integrity of the genome in the face of DNA damage is crucial to ensure the survival of the cell and normal development. DNA lesions and repair occur in the context of the chromatin fiber, whose 3D organization and movements in the restricted volume of the nucleus are under intense scrutiny. Here, we highlight work from our and other labs that addresses how the dynamic organization of the chromatin fiber affects the repair of damaged DNA and how, conversely, DNA damage and repair affect the structure and dynamics of chromatin in the budding yeast nucleus.
https://hal-pasteur.archives-ouvertes.fr/pasteur-02060127 Contributor : Marie LemesleConnect in order to contact the contributor Submitted on : Thursday, March 7, 2019 - 11:08:04 AM Last modification on : Thursday, April 7, 2022 - 10:10:36 AM
Emmanuelle Fabre, Christophe Zimmer. From dynamic chromatin architecture to DNA damage repair and back. Nucleus, European Nuclear Society, 2018, 9 (1), pp.161-170. ⟨10.1080/19491034.2017.1419847⟩. ⟨pasteur-02060127⟩