Skip to Main content Skip to Navigation
Journal articles

Whole-Genome Characterization of Epidemic Neisseria meningitidis Serogroup C and Resurgence of Serogroup W, Niger, 2015.

Abstract : In 2015, Niger reported the largest epidemic of Neisseria meningitidis serogroup C (NmC) meningitis in sub-Saharan Africa. The NmC epidemic coincided with serogroup W (NmW) cases during the epidemic season, resulting in a total of 9,367 meningococcal cases through June 2015. To clarify the phylogenetic association, genetic evolution, and antibiotic determinants of the meningococcal strains in Niger, we sequenced the genomes of 102 isolates from this epidemic, comprising 81 NmC and 21 NmW isolates. The genomes of 82 isolates were completed, and all 102 were included in the analysis. All NmC isolates had sequence type 10217, which caused the outbreaks in Nigeria during 2013-2014 and for which a clonal complex has not yet been defined. The NmC isolates from Niger were substantially different from other NmC isolates collected globally. All NmW isolates belonged to clonal complex 11 and were closely related to the isolates causing recent outbreaks in Africa.
Complete list of metadatas

Cited literature [26 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-02056224
Contributor : Marie Martin <>
Submitted on : Monday, March 4, 2019 - 2:45:37 PM
Last modification on : Wednesday, July 1, 2020 - 10:36:02 AM
Long-term archiving on: : Wednesday, June 5, 2019 - 2:44:06 PM

File

16-0468-combined.pdf
Publication funded by an institution

Licence


Distributed under a Creative Commons CC0 - Public Domain Dedication 4.0 International License

Identifiers

Collections

Citation

Cecilia Kretz, Adam Retchless, Fati Sidikou, Bassira Issaka, Sani Ousmane, et al.. Whole-Genome Characterization of Epidemic Neisseria meningitidis Serogroup C and Resurgence of Serogroup W, Niger, 2015.. Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2016, 22 (10), pp.1762-1768. ⟨10.3201/eid2210.160468⟩. ⟨pasteur-02056224⟩

Share

Metrics

Record views

118

Files downloads

240