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An embryonic story: Analysis of the gene regulative network controlling Xist expression in mouse embryonic stem cells

Pablo Navarro Gil 1 Philip Avner 1, *
* Corresponding author
Abstract : In mice, dosage compensation of X-linked gene expression is achieved through the inactivation of one of the two X-chromosomes in XX female cells. The complex epigenetic process leading to X-inactivation is largely controlled by Xist and Tsix, two non-coding genes of opposing function. Xist RNA triggers X-inactivation by coating the inactive X, while Tsix is critical for the designation of the active X-chromosome through cis-repression of Xist RNA accumulation. Recently, a plethora of trans-acting factors and cis-regulating elements have been suggested to act as key regulators of either Xist, Tsix or both; these include ubiquitous factors such as Yy1 and Ctcf, developmental proteins such as Nanog, Oct4 and Sox2, and X-linked regulators such as Rnf12. In this paper we summarise recent advances in our knowledge of the regulation of Xist and Tsix in embryonic stem (ES) and differentiating ES cells.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02025234
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Submitted on : Tuesday, February 19, 2019 - 3:37:22 PM
Last modification on : Monday, January 13, 2020 - 5:08:08 PM

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Pablo Navarro Gil, Philip Avner. An embryonic story: Analysis of the gene regulative network controlling Xist expression in mouse embryonic stem cells. BioEssays, Wiley-VCH Verlag, 2010, 32 (7), pp.581-588. ⟨10.1002/bies.201000019⟩. ⟨pasteur-02025234⟩

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