New roles for Dicer in the nucleolus and its relevance to cancer

Benjamin Roche (1) , Benoît Arcangioli (2) , Robert Martienssen (1)

1 CSHL - Cold Spring Harbor Laboratory
2 Dynamique du Génome - Dynamics of the genome

The nucleolus is a distinct compartment of the nucleus responsible for ribosome biogenesis. Mis-regulation of nucleolar functions and of the cellular translation machinery has been associated with disease, in particular with many types of cancer. Indeed, many tumor suppressors (p53, Rb, PTEN, PICT1, BRCA1) and proto-oncogenes (MYC, NPM) play a direct role in the nucleolus, and interact with the RNA polymerase I transcription machinery and the nucleolar stress response. We have identified Dicer and the RNA interference pathway as having an essential role in the nucleolus of quiescent Schizosaccharomyces pombe cells, distinct from pericentromeric silencing, by controlling RNA polymerase I release. We propose that this novel function is evolutionarily conserved and may contribute to the tumorigenic pre-disposition of DICER1 mutations in mammals.

Keywords: cancer; dicer; epigenetics; nucleolus; rDNA

Domains: Biochemistry, Molecular Biology

Benjamin Roche, Benoît Arcangioli, Robert Martienssen. New roles for Dicer in the nucleolus and its relevance to cancer. Cell Cycle, 2017, 16 (18), pp.1643-1653. ⟨10.1080/15384101.2017.1361568⟩. ⟨pasteur-02013965⟩