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Smacoviridae: a new family of animal-associated single-stranded DNA viruses

Abstract : Smacoviruses have small (∼2.3-2.9 kb), circular single-stranded DNA genomes encoding rolling circle replication-associated proteins (Rep) and unique capsid proteins. Although smacoviruses are prevalent in faecal matter of various vertebrates, including humans, none of these viruses have been cultured thus far. Smacoviruses display ∼45% genome-wide sequence diversity, which is very similar to that found within other families of circular Rep-encoding single-stranded (CRESS) DNA viruses, including members of the families Geminiviridae (46% diversity) and Genomoviridae (47% diversity). Here, we announce the creation of a new family Smacoviridae and describe a sequence-based taxonomic framework which was used to classify 83 smacovirus genomes into 43 species within six new genera, Bovismacovirus (n=3), Cosmacovirus (n=1), Dragsmacovirus (n=1), Drosmacovirus (n=3), Huchismacovirus (n=7), and Porprismacovirus (n=28). As in the case of genomoviruses, the species demarcation is based on the genome-wide pairwise identity, whereas genera are established based on the Rep amino acid sequence identity coupled with strong phylogenetic support. A similar sequence-based taxonomic framework should guide the classification of an astonishing diversity of other uncultured and currently unclassified CRESS DNA viruses discovered by metagenomic approaches.
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Submitted on : Thursday, January 10, 2019 - 4:54:18 PM
Last modification on : Wednesday, April 29, 2020 - 2:14:16 PM

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Arvind Varsani, Mart Krupovic. Smacoviridae: a new family of animal-associated single-stranded DNA viruses. Archives of Virology, Springer Verlag, 2018, 163 (7), pp.2005-2015. ⟨10.1007/s00705-018-3820-z⟩. ⟨pasteur-01977338⟩

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