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Genomic architecture of human neuroanatomical diversity

Roberto Toro 1, * J-B Poline 2, 3 G Huguet 1 E Loth 4 V. Frouin 2 T. Banaschewski 5, 6 G J Barker 4 A Bokde 7 C Büchel 8 F.M. Carvalho 4 P Conrod 4, 9 M Fauth-Bühler 5, 6 H Flor 5, 6 J Gallinat 10 H Garavan 7, 11 P Gowland 11 A. Heinz 10 B Ittermann 12 C Lawrence 13 H Lemaître 14, 15 K. Mann 5, 6 F Nees 5, 6 T Paus 13, 16, 17, 9 Z Pausova 17 M Rietschel 5, 6 T Robbins 18 M N Smolka 19 A Ströhle 10 G. Schumann 4 T. Bourgeron 1, 20 
Abstract : Human brain anatomy is strikingly diverse and highly inheritable: genetic factors may explain up to 80% of its variability. Prior studies have tried to detect genetic variants with a large effect on neuroanatomical diversity, but those currently identified account for <5% of the variance. Here, based on our analyses of neuroimaging and whole-genome genotyping data from 1765 subjects, we show that up to 54% of this heritability is captured by large numbers of single-nucleotide polymorphisms of small-effect spread throughout the genome, especially within genes and close regulatory regions. The genetic bases of neuroanatomical diversity appear to be relatively independent of those of body size (height), but shared with those of verbal intelligence scores. The study of this genomic architecture should help us better understand brain evolution and disease.
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Roberto Toro, J-B Poline, G Huguet, E Loth, V. Frouin, et al.. Genomic architecture of human neuroanatomical diversity. Molecular Psychiatry, 2015, 20 (8), pp.1011-1016. ⟨10.1038/mp.2014.99⟩. ⟨pasteur-01967180⟩



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