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Journal Articles Antimicrobial Agents and Chemotherapy Year : 2018

Acquisition of Beta-Lactamase by Neisseria meningitidis through Possible Horizontal Gene Transfer

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Abstract

We report the detection in France of a beta-lactamase-producing invasive meningococcal isolate. Whole-genome sequencing of the isolate revealed a ROB-1-type beta-lactamase gene that is frequently encountered in Haemophilus influenzae, suggesting horizontal transfer between isolates of these bacterial species. Beta-lactamases are exceptional in meningococci, with no reports for more than 2 decades. This report is worrying, as the expansion of such isolates may jeopardize the effective treatment against invasive meningococcal disease.
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pasteur-01950880 , version 1 (11-12-2018)

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Eva Hong, Ala-Eddine Deghmane, Muhamed-Kheir Taha. Acquisition of Beta-Lactamase by Neisseria meningitidis through Possible Horizontal Gene Transfer. Antimicrobial Agents and Chemotherapy, 2018, 62 (9), pp.e00831-18. ⟨10.1128/AAC.00831-18⟩. ⟨pasteur-01950880⟩

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