Skip to Main content Skip to Navigation
Journal articles

Analysis of the impact of corticosteroids adjuvant treatment during experimental invasive meningococcal infection in mice.

Abstract : Invasive meningococcal disease (IMD) is usually associated with intense inflammatory response that is correlated with severe infection. Corticosteroids may regulate this inflammatory response through an early but transient induction of IL-10 that is suggested to improve the outcome of IMD. We explored the mechanism of action of corticosteroids as an adjuvant treatment to antibiotics. Transgenic mice expressing the human transferrin were infected by a hyperinvasive meningococcal strain and transcriptomic analysis were then performed in the blood for all conditions of infection and treatment. Infected untreated mice, infected antibiotic-treated mice and infected amoxicillin and dexamethasone-treated mice were compared. Treatment using both corticosteroids and antibiotics was associated with differential gene expression in the blood especially in Monocytes-Macrophages pathways. Depletion of these cells in infected mice was associated with a more severe bacterial infection and uncontrolled production of both pro-inflammatory and anti-inflammatory cytokines. Accordingly, children suffering from severe IMD had low counts of monocytes at admission. Our data are in favor of a role of corticosteroids in enhancing a polarization from pro-inflammatory to anti-inflammatory phenotypes of Monocytes-Macrophages axis that may help controlling meningococcal invasive infections.
Document type :
Journal articles
Complete list of metadatas

Cited literature [36 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-01950877
Contributor : Muhamed-Kheir Taha <>
Submitted on : Saturday, March 30, 2019 - 8:29:41 PM
Last modification on : Saturday, April 11, 2020 - 1:57:42 AM

File

STEROIDS-D-18-00075R1_mod.pdf
Files produced by the author(s)

Licence


Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License

Identifiers

Citation

Michael Lévy, Michael Levy, Ala-Eddine Deghmane, Myriam Aouiti-Trabelsi, Stéphane Dauger, et al.. Analysis of the impact of corticosteroids adjuvant treatment during experimental invasive meningococcal infection in mice.. Steroids, Elsevier, 2018, 136, pp.32-39. ⟨10.1016/j.steroids.2018.05.007⟩. ⟨pasteur-01950877⟩

Share

Metrics

Record views

348

Files downloads

989