Skip to Main content Skip to Navigation
Journal articles

Transcriptional reprogramming in cellular quiescence

Abstract : Most cells in nature are not actively dividing, yet are able to return to the cell cycle given the appropriate environmental signals. There is now ample evidence that quiescent G0 cells are not shut-down but still metabolically and transcriptionally active. Quiescent cells must maintain a basal transcriptional capacity to maintain transcripts and proteins necessary for survival. This implies a tight control over RNA polymerases: RNA pol II for mRNA transcription during G0, but especially RNA pol I and RNA pol III to maintain an appropriate level of structural RNAs, raising the possibility that specific transcriptional control mechanisms evolved in quiescent cells. In accordance with this, we recently discovered that RNA interference is necessary to control RNA polymerase I transcription during G0. While this mini-review focuses on yeast model organisms (Saccharomyces cerevisiae and Schizosaccharomyces pombe), parallels are drawn to other eukaryotes and mammalian systems, in particular stem cells.
Document type :
Journal articles
Complete list of metadatas

Cited literature [238 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-01868271
Contributor : Benoit Arcangioli <>
Submitted on : Wednesday, September 5, 2018 - 12:00:15 PM
Last modification on : Monday, January 13, 2020 - 5:08:18 PM
Long-term archiving on: : Thursday, December 6, 2018 - 2:12:46 PM

File

Transcriptional reprogramming ...
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License

Identifiers

Collections

Citation

Benjamin Roche, Benoît Arcangioli, Robert Martienssen. Transcriptional reprogramming in cellular quiescence. RNA Biology, Taylor & Francis, 2017, 14 (7), pp.843 - 853. ⟨10.1080/15476286.2017.1327510⟩. ⟨pasteur-01868271⟩

Share

Metrics

Record views

128

Files downloads

260