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Journal articles
The spread of prion-like proteins by lysosomes and tunneling nanotubes: Implications for neurodegenerative diseases
Abstract : Progression of pathology in neurodegenerative diseases is hypothesized to be a non–cell-autonomous process
that may be mediated by the productive spreading of prion-like protein aggregates from a “donor cell” that is
the source of misfolded aggregates to an “acceptor cell” in which misfolding is propagated by conversion of the normal protein. Although the proteins involved in the various diseases are unrelated, common pathways appear to be used for their intercellular propagation and spreading. Here, we summarize recent evidence of the molecular mechanisms relevant for the intercellular trafficking of protein aggregates involved in prion, Alzheimer’s, Huntington’s, and Parkinson’s diseases. We focus in particular on the common roles that lysosomes and tunneling nanotubes play in the formation and spread-
ing of prion-like assemblies
Cited literature [146 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-01855453
Contributor : Reine Bouyssie <>
Submitted on : Wednesday, August 8, 2018 - 8:17:56 AM
Last modification on : Friday, September 18, 2020 - 2:52:03 PM
Long-term archiving on: : Friday, November 9, 2018 - 12:29:10 PM
Contributor : Reine Bouyssie <>
Submitted on : Wednesday, August 8, 2018 - 8:17:56 AM
Last modification on : Friday, September 18, 2020 - 2:52:03 PM
Long-term archiving on: : Friday, November 9, 2018 - 12:29:10 PM
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The spread of prion-like prote...
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