Identification of Molecular Markers Associated with Alteration of Receptor-Binding Specificity in a Novel Genotype of Highly Pathogenic Avian Influenza A(H5N1) Viruses Detected in Cambodia in 2013
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Veasna Duong
- Function : Author
- PersonId : 765625
- ORCID : 0000-0003-0353-1678
William Davis
- Function : Author
- PersonId : 791269
- ORCID : 0000-0002-8119-821X
Touch Sok
- Function : Author
- PersonId : 763765
- ORCID : 0000-0002-8570-5338
Arnaud Tarantola
- Function : Author
- PersonId : 18393
- IdHAL : arnaud-tarantola
- ORCID : 0000-0002-6946-7958
- IdRef : 035123044
Marc-Alain Widdowson
- Function : Author
- PersonId : 1025880
Philippe Buchy
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- Function : Correspondent author
- PersonId : 973649
Connectez-vous pour contacter l'auteur
Abstract
Human infections with influenza A(H5N1) virus in Cambodia increased sharply during 2013. Molecular characterization of viruses detected in clinical specimens from human cases revealed the presence of mutations associated with the alteration of receptor-binding specificity (K189R, Q222L) and respiratory droplet transmission in ferrets (N220K with Q222L). Discovery of quasispecies at position 222 (Q/L), in addition to the absence of the mutations in poultry/environmental samples, suggested that the mutations occurred during human infection and did not transmit further.