Identification of Molecular Markers Associated with Alteration of Receptor-Binding Specificity in a Novel Genotype of Highly Pathogenic Avian Influenza A(H5N1) Viruses Detected in Cambodia in 2013 - Archive ouverte HAL Access content directly
Journal Articles Journal of Virology Year : 2014

Identification of Molecular Markers Associated with Alteration of Receptor-Binding Specificity in a Novel Genotype of Highly Pathogenic Avian Influenza A(H5N1) Viruses Detected in Cambodia in 2013

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Touch Sok
Paul Horwood
  • Function : Author
  • PersonId : 1030168

Abstract

Human infections with influenza A(H5N1) virus in Cambodia increased sharply during 2013. Molecular characterization of viruses detected in clinical specimens from human cases revealed the presence of mutations associated with the alteration of receptor-binding specificity (K189R, Q222L) and respiratory droplet transmission in ferrets (N220K with Q222L). Discovery of quasispecies at position 222 (Q/L), in addition to the absence of the mutations in poultry/environmental samples, suggested that the mutations occurred during human infection and did not transmit further.

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pasteur-01739380 , version 1 (21-03-2018)

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Sareth Rith, C. Todd Davis, Veasna Duong, Borann Sar, Srey Viseth Horm, et al.. Identification of Molecular Markers Associated with Alteration of Receptor-Binding Specificity in a Novel Genotype of Highly Pathogenic Avian Influenza A(H5N1) Viruses Detected in Cambodia in 2013. Journal of Virology, 2014, 88 (23), pp.13897 - 13909. ⟨10.1128/JVI.01887-14⟩. ⟨pasteur-01739380⟩
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