Skip to Main content Skip to Navigation
Journal articles

Identification of Molecular Markers Associated with Alteration of Receptor-Binding Specificity in a Novel Genotype of Highly Pathogenic Avian Influenza A(H5N1) Viruses Detected in Cambodia in 2013

Abstract : Human infections with influenza A(H5N1) virus in Cambodia increased sharply during 2013. Molecular characterization of viruses detected in clinical specimens from human cases revealed the presence of mutations associated with the alteration of receptor-binding specificity (K189R, Q222L) and respiratory droplet transmission in ferrets (N220K with Q222L). Discovery of quasispecies at position 222 (Q/L), in addition to the absence of the mutations in poultry/environmental samples, suggested that the mutations occurred during human infection and did not transmit further.
Document type :
Journal articles
Complete list of metadatas

https://hal-pasteur.archives-ouvertes.fr/pasteur-01739380
Contributor : Arnaud Tarantola <>
Submitted on : Wednesday, March 21, 2018 - 12:20:18 AM
Last modification on : Thursday, February 21, 2019 - 2:26:09 PM

Links full text

Identifiers

Collections

Citation

Sareth Rith, C. Todd Davis, Veasna Duong, Borann Sar, Srey Viseth Horm, et al.. Identification of Molecular Markers Associated with Alteration of Receptor-Binding Specificity in a Novel Genotype of Highly Pathogenic Avian Influenza A(H5N1) Viruses Detected in Cambodia in 2013. Journal of Virology, American Society for Microbiology, 2014, 88 (23), pp.13897 - 13909. ⟨10.1128/JVI.01887-14⟩. ⟨pasteur-01739380⟩

Share

Metrics

Record views

137