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Journal articles
Serotype Distribution of Clinical Streptococcus pneumoniae Isolates before the Introduction of the 13-Valent Pneumococcal Conjugate Vaccine in Cambodia
Malin Inghammar
1, 2, *
Youlet By
3, 4
Christina Farris
5
Thong Phe
6
Laurence Borand
1
Alexandra Kerleguer
1
Sophie Goyet
1
Vonthanak Saphonn
4
Chanleakhena Phoeung
4
Sirenda Vong
1
Blandine Rammaert
7, 8
Charles Mayaud
1
Bertrand Guillard
1
Chadwick Yasuda
5
Matthew Kasper
5
Gavin Ford
5
Steven Newell
5
Ung Sam An
9
Buth Sokhal
9
Sok Touch
10
Paul Turner
11, 12
Jan Jacobs
6, 13, 14
Mélina Messaoudi
15
Florence Komurian-Pradel
15
Arnaud Tarantola
1
*
Corresponding author
Malin Inghammar 1, 2
Correspondent author
Youlet By 3, 4
Author
Christina Farris 5
Author
Thong Phe 6
Author
Laurence Borand 1
Author
Alexandra Kerleguer 1
Author
Sophie Goyet 1
Author
Vonthanak Saphonn 4
Author
Chanleakhena Phoeung 4
Author
Sirenda Vong 1
Author
Blandine Rammaert 7, 8
Author
Charles Mayaud 1
Author
Paul Turner 11, 12
Author
Jan Jacobs 6, 13, 14
Author
Mélina Messaoudi 15
Author
Florence Komurian-Pradel 15
Author
Arnaud Tarantola 1
Author IdHAL : arnaud-tarantola ORCID : https://orcid.org/0000-0002-6946-7958
1
Institut Pasteur du Cambodge (BP 983 - 5 , Boulevard Monivong, Phnom Penh - Cambodia)
- RIIP - Réseau International des Instituts Pasteur (25, rue du Dr Roux 75724 Paris Cedex 15 - France)
2
Skane University Hospital [Lund] (Getingevägen 4, 222 41 Lund - Sweden)
3
Fondation Mérieux (17, rue Bourgelat 69002 Lyon, France - France)
4
University of Health Science (Phnom Penh - Cambodia)
5
Naval Medical Research Unit No.2 (Phnom Penh - Cambodia)
6
Shihanouk Hospital Centre of HOPE (Phnom Penh - Cambodia)
- Shihanouk Hospital Centre of HOPE (Phnom Penh - Cambodia)
7
Médecine Interne et Maladies Infectieuses, CHU de Poitiers, Poitiers, France (France)
- CHU Poitiers - Centre hospitalier universitaire de Poitiers (2 Rue de la Milétrie, 86021 Poitiers - France)
8
PHAR - Pharmacologie des anti-infectieux (Pôle Biologie Santé, 1 rue Georges Bonnet 86022 Poitiers Cedex - France)
- Université de Poitiers : U1070 (15, rue de l'Hôtel Dieu - 86034 Poitiers Cedex - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1070 (101, rue de Tolbiac, 75013 Paris - France)
9
Cambodian National Laboratory of Public Health (Phnom Penh - Cambodia)
10
CDC MOH - Communicable Disease Department [Phnom Penh] (#151-153, Kampuchea Krom blvd, Phnom Penh - Cambodia)
- Ministry of Health [Mozambique] (Mozambique)
11
Cambodia Oxford Medical Research (Siem Reap - Cambodia)
12
Nuffield Department of Medicine (United Kingdom)
- Centre for Tropical Medicine and Global Health, University of Oxford (Oxford - United Kingdom)
13
ITM - Institute of Tropical Medicine [Antwerp] (Nationalestraat 155, 2000 Antwerp - Belgium)
14
KU Leuven - Catholic University of Leuven - Katholieke Universiteit Leuven (Oude Markt 13 - bus 5005, 3000 Leuven - Belgium)
15
CIRI - Centre International de Recherche en Infectiologie - UMR (21 avenue Tony Garnier 69365 Lyon Cedex 07 - France)
- ENS Lyon - École normale supérieure - Lyon (15 parvis René Descartes - BP 7000 - 69342 Lyon Cedex 07 - France)
- UCBL - Université Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)
- Université de Lyon (92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1111 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR5308 (France)
Abstract : Childhood vaccination with the 13-valent pneumococcal conjugate vaccine (PCV13) was introduced in Cambodia in January 2015. Baseline data regarding circulating serotypes are scarce. All microbiology laboratories in Cambodia were contacted for identification of stored isolates ofStreptococcus pneumoniaefrom clinical specimens taken before the introduction of PCV13. Available isolates were serotyped using a multiplex polymerase chain reaction method. Among 166 identified isolates available for serotyping from patients with pneumococcal disease, 4% were isolated from upper respiratory samples and 80% were from lower respiratory samples, and 16% were invasive isolates. PCV13 serotypes accounted for 60% (95% confidence interval [CI] 52-67) of all isolates; 56% (95% CI 48-64) of noninvasive and 77% (95% CI 57-89) of invasive isolates. Antibiotic resistance was more common among PCV13 serotypes. This study of clinicalS. pneumoniaeisolates supports the potential for high reduction in pneumococcal disease burden and may serve as baseline data for future monitoring ofS. pneumoniaeserotypes circulation after implementation of PCV13 childhood vaccination in Cambodia.
Document type :
Journal articles
Complete list of metadatas
https://hal-pasteur.archives-ouvertes.fr/pasteur-01739337
Contributor : Arnaud Tarantola <>
Submitted on : Tuesday, March 20, 2018 - 11:42:28 PM
Last modification on : Friday, October 23, 2020 - 4:53:37 PM
Long-term archiving on: : Tuesday, September 11, 2018 - 10:45:59 PM
Contributor : Arnaud Tarantola <>
Submitted on : Tuesday, March 20, 2018 - 11:42:28 PM
Last modification on : Friday, October 23, 2020 - 4:53:37 PM
Long-term archiving on: : Tuesday, September 11, 2018 - 10:45:59 PM
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tpmd170692.pdf
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Identifiers
- HAL Id : pasteur-01739337, version 1
- DOI : 10.4269/ajtmh.17-0692
- PUBMED : 29313476
Collections
PASTEUR | CNRS | RIIP | RIIP_CAMBODGE | UNIV-LYON1 | CIRI | ENS-LYON | UDL | UNIV-POITIERS | PHAR
Citation
Malin Inghammar, Youlet By, Christina Farris, Thong Phe, Laurence Borand, et al.. Serotype Distribution of Clinical Streptococcus pneumoniae Isolates before the Introduction of the 13-Valent Pneumococcal Conjugate Vaccine in Cambodia. American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2018, 98 (3), pp.791 - 796. ⟨10.4269/ajtmh.17-0692⟩. ⟨pasteur-01739337⟩
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