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Journal articles
Aspergillus Galactosaminogalactan Mediates Adherence to Host Constituents and Conceals Hyphal β-Glucan from the Immune System
Fabrice Gravelat
1
Anne Beauvais
2
Hong Liu
3
Mark Lee
1
Brendan Snarr
1
Dan Chen
4
Wenjie Xu
5
Ilia Kravtsov
1
Christopher Hoareau
1
Ghyslaine Vanier
1
Mirjam Urb
1
Paolo Campoli
1
Qusai Al Abdallah
1
Mélanie Lehoux
1
Josée Chabot
1
Marie-Claude Ouimet
1
Stefanie Baptista
1
Jörg H Fritz
1
William C Nierman
4
Jean Paul Latgé
2
Aaron Mitchell
5
Scott G Filler
6, 3
Thierry Fontaine
2, *
Donald Sheppard
1, *
Christopher Hoareau 1
Author
Ghyslaine Vanier 1
Author
Mirjam Urb 1
Author
Paolo V. Campoli 1
Author
Qusai Al Abdallah 1
Author
Mélanie Lehoux 1
Author
Josée C. Chabot 1
Author
Marie-Claude Ouimet 1
Author
Stefanie D. Baptista 1
Author
Jörg H Fritz 1
Author
William C Nierman 4
Author
Jean Paul Latgé 2
Author
Aaron P. Mitchell 5
Author
Scott G Filler 6, 3
Author
Thierry Fontaine 2
Correspondent author
Donald C. Sheppard 1
Correspondent author
1
McGill University = Université McGill [Montréal, Canada] (845, rue Sherbrooke O. Montréal (Québec) Canada H3A 0G4 - Canada)
2
Aspergillus (Département de parasitologie et mycologie, 25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
3
UCLA - University of California [Los Angeles] ( Los Angeles, Californie 90095 - United States)
- University of California (United States)
4
J Craig Venter Institute (United States)
5
CMU - Carnegie Mellon University [Pittsburgh] (5000 Forbes Ave, Pittsburgh, PA 15213 - United States)
6
David Geffen School of Medicine [Los Angeles] (United States)
- UCLA - University of California [Los Angeles] ( Los Angeles, Californie 90095 - United States)
- University of California (United States)
Abstract : Aspergillus fumigatus is the most common cause of invasive mold disease in humans. The mechanisms underlying the adherence of this mold to host cells and macromolecules have remained elusive. Using mutants with different adhesive properties and comparative transcriptomics, we discovered that the gene uge3, encoding a fungal epimerase, is required for adherence through mediating the synthesis of galactosaminogalactan. Galactosaminogalactan functions as the dominant adhesin of A. fumigatus and mediates adherence to plastic, fibronectin, and epithelial cells. In addition, galactosaminogalactan suppresses host inflammatory responses in vitro and in vivo, in part through masking cell wall β-glucans from recognition by dectin-1. Finally, galactosaminogalactan is essential for full virulence in two murine models of invasive aspergillosis. Collectively these data establish a role for galactosaminogalactan as a pivotal bifunctional virulence factor in the pathogenesis of invasive aspergillosis.
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Journal articles
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01726798
Contributor : Nirina Andriakoto <>
Submitted on : Thursday, March 8, 2018 - 3:36:57 PM
Last modification on : Thursday, June 18, 2020 - 12:32:05 PM
Long-term archiving on: : Saturday, June 9, 2018 - 2:49:20 PM
Contributor : Nirina Andriakoto <>
Submitted on : Thursday, March 8, 2018 - 3:36:57 PM
Last modification on : Thursday, June 18, 2020 - 12:32:05 PM
Long-term archiving on: : Saturday, June 9, 2018 - 2:49:20 PM
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journal.ppat.1003575.pdf
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Distributed under a Creative Commons Attribution 4.0 International License
Identifiers
- HAL Id : pasteur-01726798, version 1
- PUBMED : 23990787
- DOI : 10.1371/journal.ppat.1003575
- PUBMEDCENTRAL : PMC3749958
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Citation
Fabrice Gravelat, Anne Beauvais, Hong Liu, Mark Lee, Brendan Snarr, et al.. Aspergillus Galactosaminogalactan Mediates Adherence to Host Constituents and Conceals Hyphal β-Glucan from the Immune System. PLoS Pathogens, Public Library of Science, 2013, 9 (8), pp.e1003575. ⟨10.1371/journal.ppat.1003575⟩. ⟨pasteur-01726798⟩
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