Autoimmunity and autoinflammation: A systems view on signaling pathway dysregulation profiles

Arsen Arakelyan (1, 2) , Nersisyan Lilit (1, 3) , David Poghosyan (1) , Lusine Khondkaryan (1) , Anna Hakobyan (1) , Henry Lö Ffler-Wirth (4) , Evie Melanitou (5) , Hans Binder (4)

1 NAS RA - National Academy of Sciences of the Republic of Armenia [Yerevan]
2 RAU - Russian-Armenian University
3 American University of Armenia
4 Universität Leipzig
5 Département Parasites et Insectes vecteurs - Department of Parasites and Insect Vectors

Autoinflammatory and autoimmune disorders are characterized by aberrant changes in innate and adaptive immunity that may lead from an initial inflammatory state to an organ specific damage. These disorders possess heterogeneity in terms of affected organs and clinical phenotypes. However, despite the differences in etiology and phenotypic variations, they share genetic associations, treatment responses and clinical manifestations. The mechanisms involved in their initiation and development remain poorly understood, however the existence of some clear similarities between autoimmune and autoinflammatory disorders indicates variable degrees of interaction between immune-related mechanisms.

Keywords: Inflammatory diseases; Gene expression; Human genomics; Comparative genomics; Inflammasomes; Inflammatory bowel disease; Immune response; Autoimmune diseases

Domains: Animal genetics; Human genetics; Endocrinology and metabolism; Infectious diseases; Subcellular Processes [q-bio.SC]

Arsen Arakelyan, Nersisyan Lilit, David Poghosyan, Lusine Khondkaryan, Anna Hakobyan, et al.. Autoimmunity and autoinflammation: A systems view on signaling pathway dysregulation profiles. PLoS ONE, 2017, 12 (11), pp.e0187572. ⟨10.1371/journal.pone.0187572⟩. ⟨pasteur-01643667⟩