Role of endogenous acetylcholine in the control of the dopaminergic system via nicotinic receptors.

Abstract : Nicotinic acetylcholine receptors (nAChRs) are pentameric membrane protein receptors activated by the addictive drug, nicotine. However, sometimes underestimated, under physiological conditions the endogenous neurotransmitter acetylcholine is the agonist. In this mini-review, I will discuss the evidence in favour of an important role for this cholinergic activation of the dopaminergic (DAergic) system. I will focus on the literature implicating the action of acetylcholine on the somato-dendritic compartment of these neurons. This modulation is responsible for a variety of phenotypes in knock-out animals of nAChR subunits. These include locomotion, exploratory behaviour, dopamine (DA) release, and DA neuron firing patterns. The novel techniques brought to bear on these analyses, lentiviral re-expression, and repression, of nAChR subunits, and transgenic expression of hypersensitive receptors will be discussed.
Type de document :
Article dans une revue
Journal of Neurochemistry, Wiley, 2010, 114 (3), pp.641-6. 〈10.1111/j.1471-4159.2010.06798.x〉
Liste complète des métadonnées

https://hal-pasteur.archives-ouvertes.fr/pasteur-01573866
Contributeur : Anaïs Victoire <>
Soumis le : jeudi 10 août 2017 - 18:02:15
Dernière modification le : jeudi 11 janvier 2018 - 06:21:31

Lien texte intégral

Identifiants

Collections

Citation

Uwe Maskos. Role of endogenous acetylcholine in the control of the dopaminergic system via nicotinic receptors.. Journal of Neurochemistry, Wiley, 2010, 114 (3), pp.641-6. 〈10.1111/j.1471-4159.2010.06798.x〉. 〈pasteur-01573866〉

Partager

Métriques

Consultations de la notice

54