Abstract : BACKGROUND:
Th17 cells play a major role in coordinating the host defence in oropharyngeal candidiasis. In this study we investigated the involvement of the Th17 response in an animal model of vulvovaginal candidiasis (VVC).
METHODS:
To monitor the course of infection we exploited a new in vivo imaging technique.
RESULTS:
i) The progression of VVC leads to a strong influx of neutrophils in the vagina soon after the challenge which persisted despite the resolution of infection; ii) IL-17, produced by vaginal cells, particularly CD4 T cells, was detected in the vaginal wash during the infection, reaching a maximum 14 days after the challenge; iii) The amount and kinetics of IL-23 in vaginal fluids were comparable to those in vaginal cells; iv) The inhibition of Th17 differentiation led to significant inhibition of IL-17 production with consequent exacerbation of infection; v) An increased production of βdefensin 2 was manifested in cells of infected mice. This production was strongly reduced when Th17 differentiation was inhibited and was increased by rIL-17 treatment.
CONCLUSIONS:
These results imply that IL-17 and Th17, along with innate antimicrobial factors, have a role in the immune response to vaginal candidiasis.
https://hal-pasteur.archives-ouvertes.fr/pasteur-01523876
Contributor : Christelle Lenormand
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Submitted on : Wednesday, May 17, 2017 - 10:22:26 AM
Last modification on : Tuesday, May 21, 2019 - 2:48:53 PM
Long-term archiving on : Monday, August 21, 2017 - 12:44:50 AM
Donatella Pietrella, Anna Rachini, Mark Pines, Neelam Pandey, Paolo Mosci, et al.. Th17 Cells and IL-17 in Protective Immunity to Vaginal Candidiasis. PLoS ONE, Public Library of Science, 2011, 6 (7), pp.e22770. ⟨10.1371/journal.pone.0022770⟩. ⟨pasteur-01523876⟩
