Skip to Main content Skip to Navigation
New interface
Journal articles

Candida albicans biofilms: building a heterogeneous, drug-tolerant environment.

Abstract : Fungi are able to form biofilms on medical implants, causing serious infections. A better understanding of fungal biofilm formation is necessary to develop tools for detection or prevention and to identify new antifungal strategies. This review explores recent advances in the characterization at the molecular level of fungal biofilms, especially those formed by the yeast Candida albicans: the identification of complex transcriptional networks that control their formation; the pivotal role of the extracellular matrix in biofilm antifungal tolerance; and the knowledge gained on the physiology of biofilm cells and heterogeneity within these communities. These findings may help develop new, targeted therapeutic strategies.
Document type :
Journal articles
Complete list of metadata

Cited literature [44 references]  Display  Hide  Download
Contributor : christelle lenormand Connect in order to contact the contributor
Submitted on : Monday, May 15, 2017 - 5:12:21 PM
Last modification on : Thursday, April 7, 2022 - 10:10:23 AM
Long-term archiving on: : Thursday, August 17, 2017 - 1:20:17 AM


 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document




Julie Bonhomme, Christophe D'Enfert. Candida albicans biofilms: building a heterogeneous, drug-tolerant environment.. Current Opinion in Microbiology, 2013, 16 (4), pp.398-403. ⟨10.1016/j.mib.2013.03.007⟩. ⟨pasteur-01522912⟩



Record views