Abstract : T cells are the main cellular targets of the human immunodeficiency virus 1 (HIV-1). HIV-1 infection induces pleiotropic effects on the infected T cell that modify the T cell capacity to respond to antigen and facilitates virus replication. HIV-1 infection subverts the formation and function of the immunological synapse altering both actin cytoskeleton remodeling and intracellular vesicle traffic. We describe here our methods to unveil how HIV-1 and in particular its protein Nef modify vesicle traffic to the immunological synapse, perturbing the synapse activation capacity.
https://hal-pasteur.archives-ouvertes.fr/pasteur-01519883
Contributeur : Florence Jeannot
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Soumis le : mardi 9 mai 2017 - 14:41:27
Dernière modification le : vendredi 19 mai 2017 - 08:51:42
Document(s) archivé(s) le : jeudi 10 août 2017 - 13:38:01
