Abstract : T cells are the main cellular targets of the human immunodeficiency virus 1 (HIV-1). HIV-1 infection induces pleiotropic effects on the infected T cell that modify the T cell capacity to respond to antigen and facilitates virus replication. HIV-1 infection subverts the formation and function of the immunological synapse altering both actin cytoskeleton remodeling and intracellular vesicle traffic. We describe here our methods to unveil how HIV-1 and in particular its protein Nef modify vesicle traffic to the immunological synapse, perturbing the synapse activation capacity.
https://hal-pasteur.archives-ouvertes.fr/pasteur-01519883 Contributor : FLORENCE JEANNOTConnect in order to contact the contributor Submitted on : Tuesday, May 9, 2017 - 2:41:27 PM Last modification on : Thursday, April 7, 2022 - 10:10:33 AM Long-term archiving on: : Thursday, August 10, 2017 - 1:38:01 PM