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Studying the Immune Synapse in HIV-1 Infection.
Abstract : T cells are the main cellular targets of the human immunodeficiency virus 1 (HIV-1). HIV-1 infection induces pleiotropic effects on the infected T cell that modify the T cell capacity to respond to antigen and facilitates virus replication. HIV-1 infection subverts the formation and function of the immunological synapse altering both actin cytoskeleton remodeling and intracellular vesicle traffic. We describe here our methods to unveil how HIV-1 and in particular its protein Nef modify vesicle traffic to the immunological synapse, perturbing the synapse activation capacity.
https://hal-pasteur.archives-ouvertes.fr/pasteur-01519883
Contributor : Florence Jeannot <>
Submitted on : Tuesday, May 9, 2017 - 2:41:27 PM
Last modification on : Monday, January 13, 2020 - 5:08:18 PM
Long-term archiving on: : Thursday, August 10, 2017 - 1:38:01 PM
Contributor : Florence Jeannot <>
Submitted on : Tuesday, May 9, 2017 - 2:41:27 PM
Last modification on : Monday, January 13, 2020 - 5:08:18 PM
Long-term archiving on: : Thursday, August 10, 2017 - 1:38:01 PM
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