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Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation.

Ai Ing Li 1, 2 yan Li 2 Silvia Lopez-Lastra 3, 2 Ralph Stadhouders 4 Franziska Paul 5 Armanda Casrouge 2 Nicolas Serafini 2 Anne Puel 6 Jacinta Bustamante 6 Laura Surace 2 Guillemette Masse-Ranson 2 Eyal David 5 Helene Strick-Marchand 2 Lionel Le Bourhis 7 Roberto Cocchi 8 Davide Topazio 8 Paolo Graziano 8 Lucia Anna Muscarella 8 Lars Rogge 9 Xavier Norel 10 Jean-Michel Sallenave 1 Matthieu Allez 11, 7 Thomas Graf 4 Rudi W Hendriks 12 Jean-Laurent Casanova 13, 6, 14, 15 Ido Amit 5 Hans yssel 16 James P Di Santo 17, * 
Abstract : Innate lymphoid cells (ILCs) represent innate versions of T helper and cytotoxic T cells that differentiate from committed ILC precursors (ILCPs). How ILCPs give rise to mature tissue-resident ILCs remains unclear. Here, we identify circulating and tissue ILCPs in humans that fail to express the transcription factors and cytokine outputs of mature ILCs but have these signature loci in an epigenetically poised configuration. Human ILCPs robustly generate all ILC subsets in vitro and in vivo. While human ILCPs express low levels of retinoic acid receptor (RAR)-related orphan receptor C (RORC) transcripts, these cells are found in RORC-deficient patients and retain potential for EOMES(+) natural killer (NK) cells, interferon gamma-positive (IFN-γ(+)) ILC1s, interleukin (IL)-13(+) ILC2s, and for IL-22(+), but not for IL-17A(+) ILC3s. Our results support a model of tissue ILC differentiation ("ILC-poiesis"), whereby diverse ILC subsets are generated in situ from systemically distributed ILCPs in response to local environmental signals.
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Ai Ing Li, yan Li, Silvia Lopez-Lastra, Ralph Stadhouders, Franziska Paul, et al.. Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation.. Cell, Elsevier, 2017, 168 (6), pp.1086-1100.e10. ⟨10.1016/j.cell.2017.02.021⟩. ⟨pasteur-01501939⟩

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