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Journal articles
Conservation of a unique mechanism of immune evasion across the Lyssavirus genus.
Abstract : The evasion of host innate immunity by Rabies virus, the prototype of the genus Lyssavirus, depends on a unique mechanism of selective targeting of interferon-activated STAT proteins by the viral phosphoprotein (P-protein). However, the immune evasion strategies of other lyssaviruses, including several lethal human pathogens, are unresolved. Here, we show that this mechanism is conserved between the most distantly related members of the genus, providing important insights into the pathogenesis and potential therapeutic targeting of lyssaviruses.
Keywords :
Signal Transduction/immunology
Sequence Homology
Amino Acid
Host-Pathogen Interactions/immunology
Humans
Immunity
Innate
Interferon Type I/metabolism
Lyssavirus/classification/*genetics/*immunology/pathogenicity
Molecular Sequence Data
Rabies virus/genetics/immunology/pathogenicity
Conserved Sequence
Animals
Amino Acid Sequence
Species Specificity
STAT Transcription Factors/immunology
Viral Proteins/genetics/immunology
https://hal-pasteur.archives-ouvertes.fr/pasteur-01481638
Contributor : Anne Lassailly-Bondaz <>
Submitted on : Friday, March 17, 2017 - 3:44:06 PM
Last modification on : Tuesday, June 16, 2020 - 4:04:07 PM
Contributor : Anne Lassailly-Bondaz <>
Submitted on : Friday, March 17, 2017 - 3:44:06 PM
Last modification on : Tuesday, June 16, 2020 - 4:04:07 PM
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J. Virol.-2012-Wiltzer-10194-9...
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