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Interaction of rabies virus P-protein with STAT proteins is critical to lethal rabies disease.

Résumé : Rabies virus (RABV) causes rabies disease resulting in >55,000 human deaths/year. The multifunctional RABV P-protein has essential roles in genome replication, and forms interactions with cellular STAT proteins that are thought to underlie viral antagonism of interferon-dependent immunity. However, the molecular details of P-protein-STAT interaction, and its importance to disease are unresolved.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01479389
Contributor : Anne Lassailly-Bondaz <>
Submitted on : Tuesday, February 28, 2017 - 5:47:52 PM
Last modification on : Tuesday, June 16, 2020 - 3:34:02 PM

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Linda Wiltzer, Kazuma Okada, Satoko Yamaoka, Florence Larrous, Henna Veera Kuusisto, et al.. Interaction of rabies virus P-protein with STAT proteins is critical to lethal rabies disease.. Journal of Infectious Diseases, Oxford University Press (OUP), 2014, 209 (11), pp.1744-53. ⟨10.1093/infdis/jit829⟩. ⟨pasteur-01479389⟩

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