The effects of mosquito saliva on dengue virus infectivity in humans.

Abstract : Arboviruses such as Dengue, Chikungunya, and Zika viruses represent a major public health problem due to globalization and propagation of susceptible vectors worldwide. Arthropod vector-derived salivary factors have the capacity to modulate human cells function by enhancing or suppressing viral replication and, therefore, modify the establishment of local and systemic viral infection. Here, we discuss how mosquito saliva may interfere with Dengue virus (DENV) infection in humans. Identification of saliva factors that enhance infectivity will allow the production of vector-based vaccines and therapeutics that would interfere with viral transmission by targeting arthropod saliva components. Understanding the role of salivary proteins in DENV transmission will provide tools to control not only Dengue but also other arboviral diseases transmitted by the same vectors.
Complete list of metadatas

https://hal-pasteur.archives-ouvertes.fr/pasteur-01453403
Contributor : Valérie Choumet <>
Submitted on : Thursday, February 2, 2017 - 5:40:20 PM
Last modification on : Thursday, January 11, 2018 - 6:23:40 AM

Identifiers

Citation

Sineewanlaya Wichit, Pauline Ferraris, Valérie Choumet, Dorothée Missé. The effects of mosquito saliva on dengue virus infectivity in humans.. Current Opinion in Virology, Elsevier, 2016, 21, pp.139-145. ⟨10.1016/j.coviro.2016.10.001⟩. ⟨pasteur-01453403⟩

Share

Metrics

Record views

74