Mucin-like peptides from Echinococcus granulosus induce antitumor activity

Abstract : There is substantial evidence suggesting that certain parasites can have antitumor properties. We evaluated mucin peptides derived from the helminth Echinococcus granulosus (denominated Egmuc) as potential inducers of antitumor activity. We present data showing that Egmuc peptides were capable of inducing an increase of activated NK cells in the spleen of immunized mice, a fact that was correlated with the capacity of splenocytes to mediate killing of tumor cells. We demonstrated that Egmuc peptides enhance LPS-induced maturation of dendritic cells in vitro by increasing the production of IL-12p40p70 and IL-6 and that Egmuc-treated DCs may activate NK cells, as judged by an increased expression of CD69. This evidence may contribute to the design of tumor vaccines and open new horizons in the use of parasite-derived molecules in the fight against cancer.
Type de document :
Article dans une revue
International Journal of Oncology, Spandidos Publications, 2013, 〈10.3892/ijo.2013.2000〉
Liste complète des métadonnées

https://hal-pasteur.archives-ouvertes.fr/pasteur-01423099
Contributeur : Françoise Baleux <>
Soumis le : mercredi 28 décembre 2016 - 14:48:22
Dernière modification le : jeudi 20 septembre 2018 - 13:56:06
Document(s) archivé(s) le : mardi 21 mars 2017 - 05:22:31

Fichier

ijo_43_3_775_PDF.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Collections

Citation

Verónica Noya, Sylvie Bay, María Florencia Festari, Enrique P. García, Ernesto Rodriguez, et al.. Mucin-like peptides from Echinococcus granulosus induce antitumor activity. International Journal of Oncology, Spandidos Publications, 2013, 〈10.3892/ijo.2013.2000〉. 〈pasteur-01423099〉

Partager

Métriques

Consultations de la notice

99

Téléchargements de fichiers

133