 |
Journal articles
Exploitation of the Host Cell Membrane Fusion Machinery by Leishmania Is Part of the Infection Process.
Abstract : Successful vacuolar pathogens have developed sophisticated strategies to hijack the endomembrane system of host cells, sabotage their signal transduction pathways, and evade antimicrobial responses. The protozoan parasite Leishmania, the causative agent of leishmaniases in humans, is particularly adept at transforming the macrophage into a hospitable host cell. Here, we describe how Leishmania promastigotes subvert the macrophage membrane fusion machinery to create an intracellular compartment favorable to the establishment of infection and to manipulate host immune responses.
Cited literature [24 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-01421184
Contributor : Michel Courcelles <>
Submitted on : Wednesday, December 21, 2016 - 5:31:41 PM
Last modification on : Monday, October 8, 2018 - 5:44:05 PM
Long-term archiving on: : Tuesday, March 21, 2017 - 4:26:43 AM
Contributor : Michel Courcelles <>
Submitted on : Wednesday, December 21, 2016 - 5:31:41 PM
Last modification on : Monday, October 8, 2018 - 5:44:05 PM
Long-term archiving on: : Tuesday, March 21, 2017 - 4:26:43 AM
File
journal.ppat.1005962.pdf
Publication funded by an institution
Licence
Distributed under a Creative Commons Attribution 4.0 International License