Travel- and Community-Based Transmission of Multidrug-Resistant Shigella sonnei Lineage among International Orthodox Jewish Communities.

Abstract : Shigellae are sensitive indicator species for studying trends in the international transmission of antimicrobial-resistant Enterobacteriaceae. Orthodox Jewish communities (OJCs) are a known risk group for shigellosis; Shigella sonnei is cyclically epidemic in OJCs in Israel, and sporadic outbreaks occur in OJCs elsewhere. We generated whole-genome sequences for 437 isolates of S. sonnei from OJCs and non-OJCs collected over 22 years in Europe (the United Kingdom, France, and Belgium), the United States, Canada, and Israel and analyzed these within a known global genomic context. Through phylogenetic and genomic analysis, we showed that strains from outbreaks in OJCs outside of Israel are distinct from strains in the general population and relate to a single multidrug-resistant sublineage of S. sonnei that prevails in Israel. Further Bayesian phylogenetic analysis showed that this strain emerged approximately 30 years ago, demonstrating the speed at which antimicrobial drug-resistant pathogens can spread widely through geographically dispersed, but internationally connected, communities.
Type de document :
Article dans une revue
Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2016, 22 (9), pp.1545-53. 〈10.3201/eid2209.151953〉
Liste complète des métadonnées

Littérature citée [29 références]  Voir  Masquer  Télécharger

https://hal-pasteur.archives-ouvertes.fr/pasteur-01421099
Contributeur : Marie Lemesle <>
Soumis le : mercredi 21 décembre 2016 - 15:33:42
Dernière modification le : lundi 8 octobre 2018 - 17:44:08
Document(s) archivé(s) le : lundi 20 mars 2017 - 16:40:46

Fichier

15-1953.pdf
Publication financée par une institution

Licence


Domaine public

Identifiants

Collections

Citation

Kate S Baker, Timothy J Dallman, Adi Behar, François-Xavier Weill, Malika Gouali, et al.. Travel- and Community-Based Transmission of Multidrug-Resistant Shigella sonnei Lineage among International Orthodox Jewish Communities.. Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2016, 22 (9), pp.1545-53. 〈10.3201/eid2209.151953〉. 〈pasteur-01421099〉

Partager

Métriques

Consultations de la notice

186

Téléchargements de fichiers

240