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Immunodominance of HLA-B27-restricted HIV KK10-specific CD8(+) T-cells is not related to naïve precursor frequency

Abstract : The factors that determine the immunodominance, efficacy and almost ubiquitous presence of CD8(+) T-cell responses to the HLA-B27-restricted HIV-1 p24 Gag-derived KK10 epitope remain to be fully elucidated. Here, we show that neither the precursor frequency nor the priming capacity of KK10-reactive CD8(+) T-cells within the naïve pool differ substantially in comparison to other specificities. These data implicate alternative mechanisms in the relative protection conferred by CD8(+) T-cell responses to this epitope.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01420532
Contributor : Marie-Genevieve Guibert <>
Submitted on : Tuesday, December 20, 2016 - 4:58:56 PM
Last modification on : Monday, October 5, 2020 - 2:20:08 PM
Long-term archiving on: : Monday, March 20, 2017 - 8:29:30 PM

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Maria Candela Iglesias, Olivia Briceño, Emma Gostick, Arnaud Moris, Céline Meaudre, et al.. Immunodominance of HLA-B27-restricted HIV KK10-specific CD8(+) T-cells is not related to naïve precursor frequency. Immunology Letters, Elsevier, 2013, 149 (1-2), pp.119--122. ⟨10.1016/j.imlet.2012.10.002⟩. ⟨pasteur-01420532⟩

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