Immunodominance of HLA-B27-restricted HIV KK10-specific CD8(+) T-cells is not related to naïve precursor frequency

Maria Candela Iglesias (1) , Olivia Briceño (1) , Emma Gostick (2) , Arnaud Moris (1) , Céline Meaudre (1) , David A. Price (2) , Marie-Noelle Ungeheuer (3) , Asier Saez-Cirion (4) , Roberto Mallone (5) , Victor Appay (1)

1 Immunité et Infection
2 School of Medicine [Cardiff]
3 ICAReB - Investigation Clinique et d’Accès aux Ressources Biologiques (Plate-forme) - Clinical Investigation and Access to BioResources
4 Régulation des Infections Rétrovirales
5 Inserm U986

The factors that determine the immunodominance, efficacy and almost ubiquitous presence of CD8(+) T-cell responses to the HLA-B27-restricted HIV-1 p24 Gag-derived KK10 epitope remain to be fully elucidated. Here, we show that neither the precursor frequency nor the priming capacity of KK10-reactive CD8(+) T-cells within the naïve pool differ substantially in comparison to other specificities. These data implicate alternative mechanisms in the relative protection conferred by CD8(+) T-cell responses to this epitope.

Keywords: Male; Humans; Female; HIV-1; HIV Core Protein p24; CD8-Positive T-Lymphocytes; Epitopes; T-Lymphocyte; HLA-B27 Antigen

Domains: Life Sciences [q-bio]; Immunology

Maria Candela Iglesias, Olivia Briceño, Emma Gostick, Arnaud Moris, Céline Meaudre, et al.. Immunodominance of HLA-B27-restricted HIV KK10-specific CD8(+) T-cells is not related to naïve precursor frequency. Immunology Letters, 2013, 149 (1-2), pp.119--122. ⟨10.1016/j.imlet.2012.10.002⟩. ⟨pasteur-01420532⟩