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Polyfunctional HIV-specific T cells in Post-Treatment Controllers

Abstract : To further understand the exceptional HIV-1 control observed in Post-Treatment Controllers (PTCs) from the Virological and Immunological Sustained CONtrol after Treatment Interruption study we investigated their HIV-specific T-cell responses. Polyfunctionality of HIV-specific CD4 and CD8 T cells and the ratios of HIV-specific CD4 T cells per infected cells were similar in post-treatment controllers, continuously early-treated patients and long-term non-progressors Overall early treatment appears to preserve robust HIV-specific CD4 T cells, which might contribute to the posttreatment control of HIV.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01420411
Contributor : Marie-Genevieve Guibert <>
Submitted on : Tuesday, December 20, 2016 - 3:28:12 PM
Last modification on : Wednesday, August 19, 2020 - 11:17:22 AM

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Assia Samri, Charlin Bacchus-Souffan, Laurent Hocqueloux, Véronique Avettand-Fenoel, Benjamin Descours, et al.. Polyfunctional HIV-specific T cells in Post-Treatment Controllers. AIDS (London, England), 2016, 30 (15), pp.2299--2302. ⟨10.1097/QAD.0000000000001195⟩. ⟨pasteur-01420411⟩

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