Polyfunctional HIV-specific T cells in Post-Treatment Controllers

Assia Samri (1, 2) , Charlin Bacchus-Souffan (2, 1) , Laurent Hocqueloux (3) , Véronique Avettand-Fenoel (4, 5) , Benjamin Descours (2, 1) , Ioannis Theodorou (6, 2, 1) , Martin Larsen (6, 2, 1) , Asier Sáez-Cirión (7) , Christine Rouzioux (4) , Brigitte Autran (6, 2, 1) , Anrs Visconti Study Group

1 SU - Sorbonne Université
2 CIMI - Centre d'Immunologie et de Maladies Infectieuses
3 CHRO - Centre Hospitalier Régional d'Orléans
4 UPD5 Médecine - Université Paris Descartes - Faculté de Médecine
5 Laboratoire de Virologie [CHU Necker]
6 Service d'Immunologie [CHU Pitié-Salpétrière]
7 HIV, Inflammation et persistance - HIV, Inflammation and Persistence

To further understand the exceptional HIV-1 control observed in Post-Treatment Controllers (PTCs) from the Virological and Immunological Sustained CONtrol after Treatment Interruption study we investigated their HIV-specific T-cell responses. Polyfunctionality of HIV-specific CD4 and CD8 T cells and the ratios of HIV-specific CD4 T cells per infected cells were similar in post-treatment controllers, continuously early-treated patients and long-term non-progressors Overall early treatment appears to preserve robust HIV-specific CD4 T cells, which might contribute to the posttreatment control of HIV.

Domains: Life Sciences [q-bio]; Immunology

Assia Samri, Charlin Bacchus-Souffan, Laurent Hocqueloux, Véronique Avettand-Fenoel, Benjamin Descours, et al.. Polyfunctional HIV-specific T cells in Post-Treatment Controllers. AIDS (London, England), 2016, 30 (15), pp.2299--2302. ⟨10.1097/QAD.0000000000001195⟩. ⟨pasteur-01420411⟩