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Traitement précoce des nourrissons vivant avec le VIH-1

Abstract : HIV-1 infection has several distinctive features in children compared to adults, especially (i) the occurrence of the primary infection during a period of high vulnerability because of the immaturity of the immune system, which partly explains that around 15% of children experience a rapidly unfavourable clinical course with death before 3-4 years-of-age (in the absence of antiretroviral therapy (ART)), and (ii) the capacity of immune restoration under ART is higher in children than in adults, which is probably partly explained by an improved thymic activity. Thus, it has recently been suggested that early ART initiation in HIV-1-infected children could protect the immune system from HIV-induced damages during the critical period of immunological immaturity. This “protective” effect could have a long-term impact, partly because specific immune responses against HIV could be developed more efficiently in case of later re-exposure to HIV viremia. Finally, early ART initiation could also have virological benefits, because of the drastic reduction of the size of the viral reservoir.
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Submitted on : Friday, December 16, 2016 - 12:27:09 PM
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Pierre Frange, Véronique Avettand-Fenoël, Florence Buseyne. Traitement précoce des nourrissons vivant avec le VIH-1 . Médecine thérapeutique / Pédiatrie, John Libbey Eurotext, 2016, 19 (1), pp.59-66. ⟨10.1684/mtp.2016.0581⟩. ⟨pasteur-01418106⟩



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