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Synthetic lethality between PAXX and XLF in mammalian development.

Abstract : PAXX was identified recently as a novel nonhomologous end-joining DNA repair factor in human cells. To characterize its physiological roles, we generated Paxx-deficient mice. Like Xlf −/− mice, Paxx −/− mice are viable, grow normally , and are fertile but show mild radiosensitivity. Strikingly, while Paxx loss is epistatic with Ku80, Lig4, and Atm deficiency, Paxx/Xlf double-knockout mice display embryonic lethality associated with genomic instability , cell death in the central nervous system, and an almost complete block in lymphogenesis, phenotypes that closely resemble those of Xrcc4 −/− and Lig4 −/− mice. Thus, combined loss of Paxx and Xlf is synthetic-lethal in mammals.
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Submitted on : Wednesday, December 14, 2016 - 4:37:02 PM
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Gabriel Balmus, Ana C. Barros, Paul W.G. Wijnhoven, Chloé Lescale, Hélène P Lenden Hasse, et al.. Synthetic lethality between PAXX and XLF in mammalian development.. Genes and Development, Cold Spring Harbor Laboratory Press, 2016, 30 (19), pp.2152 - 2157. ⟨10.1101/gad.290510.116⟩. ⟨pasteur-01416628⟩

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