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Journal articles
Long-Term Spontaneous Control of HIV-1 Is Related to Low Frequency of Infected Cells and Inefficient Viral Reactivation.
Nicolas Noel
1
Ruth Peña
2
Annie David
3
Veronique Avettand-Fenoel
4
Itziar Erkizia
2
Esther Jimenez
2
Camille Lecuroux
1
Christine Rouzioux
4
Faroudy Boufassa
5
Gianfranco Pancino
6
Alain Venet
1
Carine van Lint
7
Javier Martinez-Picado
8, 2, 9
Olivier Lambotte
1
Asier Sáez-Cirión
3, *
Julia G. Prado
2, *
*
Corresponding author
5
U1018
Itziar Erkizia 2
Author
Esther Jimenez 2
Author
Camille Lecuroux 1
Author
Christine Rouzioux 4
Author
Javier Martinez-Picado 8, 2, 9
Author
Olivier Lambotte 1
Author
Asier Sáez-Cirión 3
Correspondent author IdHAL : asier-saez-cirion ORCID : https://orcid.org/0000-0003-2406-7536
Julia G. Prado 2
Correspondent author
1
IMVA - U1184 - Immunologie des Maladies Virales et Autoimmunes (Site de l'Hôpital de Bicêtre - Faculté de Médecine Paris Sud - 63 rue Gabriel Péri 94276 Le Kremlin-Bicêtre Cedex.
Site du CEA de Fontenay-aux-Roses - 10, route du Panorama - BP 6 - 92265 Fontenay-aux-Roses. - France)
- UP11 - Université Paris-Sud - Paris 11 (Bâtiment 300 - 91405 Orsay cedex - France)
- CEA - Commissariat à l'énergie atomique et aux énergies alternatives : DRF/IMETI (Centre de Saclay Centre de Grenoble Centre de Cadarache etc - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1184 (101, rue de Tolbiac, 75013 Paris - France)
2
IrsiCaixa (Institut de Recerca de la Sida) (Institut de Recerca del Sida IrsiCaixa, Hospital Germans Trias i Pujol, Ctra. de Canyet, s/n, 08916 Badalona (Barcelona) - Spain)
3
HIV, Inflammation et persistance (Département Virologie, 25-28 rue du Docteur Roux, 75724 Paris cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
4
Laboratoire de Virologie [CHU Necker] (149, rue de Sèvres 75743 PARIS Cedex 15 - France)
- CHU Necker - Enfants Malades [AP-HP] (149 Rue de Sèvres 75015 Paris - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
5
U1018 (Le Kremlin -Bicêtre - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale (101, rue de Tolbiac, 75013 Paris - France)
6
Régulation des Infections Rétrovirales (25 rue du Dr Roux, 75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
7
Service de Virologie Moléculaire, IBMM, Université Libre de Bruxelles (Belgium)
- ULB - Université libre de Bruxelles (Avenue Franklin Roosevelt 50 - 1050 Bruxelles - Belgium)
8
ICREA - Institució Catalana de Recerca i Estudis Avançats (Passeig Lluís Companys 23, 08010 Barcelona - Spain)
9
Universitat de Vic (Universitat Central de Catalunya, Sagrada Família, 7, 08500 Vic - Spain)
Abstract : HIV establishes reservoirs of infected cells that persist despite effective antiretroviral therapy (ART). In most patients, the virus begins to replicate soon after treatment interruption. However, a low frequency of infected cells at the time of treatment interruption has been associated with delayed viral rebound. Likewise, individuals who control the infection spontaneously, so-called HIV-1 controllers (HICs), carry particularly low levels of infected cells. It is unclear, however, whether and how this small number of infected cells contributes to durable viral control. Here we compared 38 HICs with 12 patients on effective combined antiretroviral therapy (cART) and found that the low frequency of infected cells in the former subjects was associated both with less efficient viral reactivation in resting CD4+ T cells and with less efficient virion production ex vivo. We also found that a potent HIV-specific CD8+ T cell response was present only in those HICs whose CD4+ T cells produced virus ex vivo. Long-term spontaneous control of HIV infection in HICs thus appears to be sustained on the basis of the inefficient reactivation of viruses from a limited number of infected cells and the capacity of HICs to activate a potent HIV-specific CD8+ T cell response to counteract efficient viral reactivation events.
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Journal articles
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https://hal-pasteur.archives-ouvertes.fr/pasteur-01414933
Contributor : Asier Saez-Cirion Connect in order to contact the contributor
Submitted on : Monday, December 12, 2016 - 4:43:11 PM
Last modification on : Tuesday, October 19, 2021 - 10:27:49 PM
Long-term archiving on: : Tuesday, March 28, 2017 - 12:47:38 AM
Contributor : Asier Saez-Cirion Connect in order to contact the contributor
Submitted on : Monday, December 12, 2016 - 4:43:11 PM
Last modification on : Tuesday, October 19, 2021 - 10:27:49 PM
Long-term archiving on: : Tuesday, March 28, 2017 - 12:47:38 AM
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Identifiers
- HAL Id : pasteur-01414933, version 1
- DOI : 10.1128/JVI.00419-16
- PUBMED : 27122576
- PUBMEDCENTRAL : PMC4907242
Collections
PASTEUR | CEA | UNIV-PARIS5 | USPC | INSERM
Citation
Nicolas Noel, Ruth Peña, Annie David, Veronique Avettand-Fenoel, Itziar Erkizia, et al.. Long-Term Spontaneous Control of HIV-1 Is Related to Low Frequency of Infected Cells and Inefficient Viral Reactivation.. Journal of Virology, American Society for Microbiology, 2016, 90 (13), pp.6148 - 6158. ⟨10.1128/JVI.00419-16⟩. ⟨pasteur-01414933⟩
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