Azole preexposure affects the Aspergillus fumigatus population in patients

Alexandre Alanio 1, 2 Odile Cabaret 2 Emilie Sitterlé 2 Jean-Marc Costa 2 Sylvain Brisse 3 Catherine Cordonnier 4 Stephane Bretagne 2, 1
1 Mycologie moléculaire
2 Laboratoire de parasitologie mycologie
3 PF8 - Génotypage des Pathogènes et Santé Publique (Plate-forme)
4 Service d'hématologie clinique
Abstract : The relationship between the azole preexposure of 86 patients and the genotype, azole susceptibility, and cyp51A polymorphisms of 110 corresponding Aspergillus fumigatus isolates was explored. Isolates carrying serial polymorphisms (F46Y and M172V with or without N248T with or without D255E with or without E427K) had higher itraconazole MICs (P = 0.04), although \textless2 μg/ml using the EUCAST methodology, were associated with two genetic clusters (P \textless 0.001) and with voriconazole preexposure of patients (P = 0.016). Voriconazole preexposure influences the distribution of A. fumigatus isolates with selection of isolates carrying cyp51A polymorphisms and higher itraconazole MICs.
Keywords : Polymorphism Single Nucleotide Pyrimidines Triazoles voriconazole Multigene Family Microbial Sensitivity Tests Antifungal Agents Aspergillosis Aspergillus fumigatus Cytochrome P-450 Enzyme System Drug Resistance Fungal Fungal Proteins Genotype Humans Itraconazole
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Article dans une revue
Antimicrobial Agents and Chemotherapy, 2012, 56 (9), pp.4948--4950. 〈10.1128/AAC.05990-11〉
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Contributeur : Floran Bidault <>
Soumis le : mardi 29 novembre 2016 - 16:26:37
Dernière modification le : jeudi 11 janvier 2018 - 06:21:36

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Alexandre Alanio, Odile Cabaret, Emilie Sitterlé, Jean-Marc Costa, Sylvain Brisse, et al.. Azole preexposure affects the Aspergillus fumigatus population in patients. Antimicrobial Agents and Chemotherapy, 2012, 56 (9), pp.4948--4950. 〈10.1128/AAC.05990-11〉. 〈pasteur-01405250〉

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