Skip to Main content Skip to Navigation
Journal articles

Preventing Biofilm Formation and Associated Occlusion by Biomimetic Glycocalyxlike Polymer in Central Venous Catheters: Biomimetic bacterial anti-adhesive strategy

Abstract : The use of catheters and other implanted devices is constantly increasing in modern medicine. Although catheters improve patients' healthcare, the hydrophobic nature of their surface material promotes protein adsorption and cell adhesion. Catheters are therefore prone to complications, such as colonization by bacterial and fungal biofilms, associated infections, and thrombosis. Here we describe the in vivo efficacy of biologically inspired glycocalyxlike antiadhesive coatings to inhibit Staphylococcus aureus and Pseudomonas aeruginosa colonization on commercial totally implantable venous access ports (TIVAPs) in a clinically relevant rat model of biofilm infection. Although noncoated TIVAPs implanted in rats were heavily colonized by the 2 biofilm-forming pathogens with a high percentage of occlusion, coating TIVAPs reduced their initial adherence and subsequently led to 4-log reduction in biofilm formation and reduced occlusion. Our antiadhesive approach is a simple and generalizable strategy that could be used to minimize clinical complications associated with the use of implantable medical devices.
Document type :
Journal articles
Complete list of metadatas

Cited literature [9 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-01381822
Contributor : Anne Lassailly-Bondaz <>
Submitted on : Thursday, November 17, 2016 - 5:35:35 PM
Last modification on : Tuesday, July 21, 2020 - 3:59:16 AM
Long-term archiving on: : Thursday, March 16, 2017 - 5:29:34 PM

File

Post-Print-ChauhanetalJID2014....
Files produced by the author(s)

Licence


Distributed under a Creative Commons Attribution - NonCommercial 4.0 International License

Identifiers

Citation

Ashwini Chauhan, Aude Bernardin, Windy Mussard, Irène Kriegel, Marc Estève, et al.. Preventing Biofilm Formation and Associated Occlusion by Biomimetic Glycocalyxlike Polymer in Central Venous Catheters: Biomimetic bacterial anti-adhesive strategy. Journal of Infectious Diseases, Oxford University Press (OUP), 2014, 210 (9), pp.1347 - 1356. ⟨10.1093/infdis/jiu249⟩. ⟨pasteur-01381822⟩

Share

Metrics