Skip to Main content Skip to Navigation
Journal articles

DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells.

Abstract : Early interactions between lung dendritic cells (LDCs) and Mycobacterium tuberculosis, the etiological agent of tuberculosis, are thought to be critical for mounting a protective anti-mycobacterial immune response and for determining the outcome of infection. However, these interactions are poorly understood, at least at the molecular level. Here we show that M. tuberculosis enters human monocyte-derived DCs after binding to the recently identified lectin DC-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN). By contrast, complement receptor (CR)3 and mannose receptor (MR), which are the main M. tuberculosis receptors on macrophages (Mphis), appeared to play a minor role, if any, in mycobacterial binding to DCs. The mycobacteria-specific lipoglycan lipoarabinomannan (LAM) was identified as a key ligand of DC-SIGN. Freshly isolated human LDCs were found to express DC-SIGN, and M. tuberculosis-derived material was detected in CD14(-)HLA-DR(+)DC-SIGN(+) cells in lymph nodes (LNs) from patients with tuberculosis. Thus, as for human immunodeficiency virus (HIV), which is captured by the same receptor, DC-SIGN-mediated entry of M. tuberculosis in DCs in vivo is likely to influence bacterial persistence and host immunity.
Document type :
Journal articles
Complete list of metadata

Cited literature [31 references]  Display  Hide  Download
Contributor : Isma Ziani Connect in order to contact the contributor
Submitted on : Tuesday, September 27, 2016 - 3:38:07 PM
Last modification on : Thursday, April 7, 2022 - 10:10:31 AM
Long-term archiving on: : Wednesday, December 28, 2016 - 1:53:20 PM


Publisher files allowed on an open archive




Ludovic Tailleux, Olivier Schwartz, Jean-Louis Herrmann, Elisabeth Pivert, Mary Jackson, et al.. DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells.. Journal of Experimental Medicine, Rockefeller University Press, 2003, 197 (1), pp.121-7. ⟨10.1084/jem.20021468⟩. ⟨pasteur-01372712⟩



Record views


Files downloads