 |
Journal articles
Identification of cryptic MHC I-restricted epitopes encoded by HIV-1 alternative reading frames.
Abstract : Human immunodeficiency virus (HIV) 1 major histocompatibility complex (MHC) I-restricted epitopes are widely believed to be derived from viral proteins encoded by primary open reading frames. However, the HIV-1 genome contains alternative reading frames (ARFs) potentially encoding small polypeptides. We have identified a panel of epitopes encoded by ARFs within the gag, pol, and env genes. The corresponding epitopic peptides were immunogenic in mice humanized for MHC-I molecules. In addition, cytotoxic T lymphocytes recognizing these epitopes were found in HIV-infected patients. These results reveal the existence of atypical mechanisms of HIV-1 epitope generation. They indicate that the repertoire of epitopes recognized by the cellular anti-HIV-1 immune response is broader than initially thought. This should be taken into account when designing vaccine strategies aimed at activating these responses.
Cited literature [44 references]
https://hal-pasteur.archives-ouvertes.fr/pasteur-01372661
Contributor : Isma Ziani <>
Submitted on : Tuesday, September 27, 2016 - 3:00:38 PM
Last modification on : Wednesday, August 19, 2020 - 11:18:11 AM
Long-term archiving on: : Wednesday, December 28, 2016 - 1:55:55 PM
Contributor : Isma Ziani <>
Submitted on : Tuesday, September 27, 2016 - 3:00:38 PM
Last modification on : Wednesday, August 19, 2020 - 11:18:11 AM
Long-term archiving on: : Wednesday, December 28, 2016 - 1:55:55 PM
File
1053.full.pdf
Publisher files allowed on an open archive
Licence
Distributed under a Creative Commons Attribution - NonCommercial - ShareAlike 4.0 International License