Skip to Main content Skip to Navigation
Journal articles

RNA and beta-Hemolysin of Group B Streptococcus Induce Interleukin-1 beta ( IL-1 beta) by Activating NLRP3 Inflammasomes in Mouse Macrophages

Abstract : The inflammatory cytokine IL-1β is critical for host responses against many human pathogens. Here, we define Group B Streptococcus (GBS)-mediated activation of the Nod-like receptor-P3 (NLRP3) inflammasome in macrophages. NLRP3 activation requires GBS expression of the cytolytic toxin, β-hemolysin, lysosomal acidification, and leakage. These processes allow the interaction of GBS RNA with cytosolic NLRP3. The present study supports a model in which GBS RNA, along with lysosomal components including cathepsins, leaks out of lysosomes and interacts with NLRP3 to induce IL-1β production.
Document type :
Journal articles
Complete list of metadatas

https://hal-pasteur.archives-ouvertes.fr/pasteur-01299773
Contributor : Anne Lassailly-Bondaz <>
Submitted on : Friday, April 8, 2016 - 12:26:57 PM
Last modification on : Monday, October 19, 2020 - 2:34:03 PM

Links full text

Identifiers

Collections

Citation

Rahul Gupta, Shubhendu Ghosh, Brian Monks, Rosane B. Deoliveira, Te-Chen Tzeng, et al.. RNA and beta-Hemolysin of Group B Streptococcus Induce Interleukin-1 beta ( IL-1 beta) by Activating NLRP3 Inflammasomes in Mouse Macrophages. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2014, 289 (20), pp.13701-13705. ⟨10.1074/jbc.C114.548982⟩. ⟨pasteur-01299773⟩

Share

Metrics

Record views

159