 |
Journal articles
RNA and beta-Hemolysin of Group B Streptococcus Induce Interleukin-1 beta ( IL-1 beta) by Activating NLRP3 Inflammasomes in Mouse Macrophages
Rahul Gupta
1
Shubhendu Ghosh
1
Brian Monks
1
Rosane B. Deoliveira
1
Te-Chen Tzeng
1
Parisa Kalantari
1
Anubhab Nandy
1
Bornali Bhattacharjee
1
Jennie Chan
1
Fabianno Ferreira
2
Vijay Rathinam
1
Shruti Sharma
1
Egil Lien
1
Neal Silverman
1
Katherine Fitzgerald
1
Arnaud Firon
3
Patrick Trieu-Cuot
3
Philipp Henneke
4
Douglas T. Golenbock
1, *
Te-Chen Tzeng 1
Author
Parisa Kalantari 1
Author
Anubhab Nandy 1
Author
Bornali Bhattacharjee 1
Author
Egil Lien 1
Author
Neal Silverman 1
Author
Katherine Fitzgerald 1
Author
Arnaud Firon 3
Author IdHAL : arnaud-firon ORCID : https://orcid.org/0000-0002-5323-5212
Patrick Trieu-Cuot 3
Author IdHAL : patricktrieu-cuot ORCID : https://orcid.org/0000-0002-2768-9587
Philipp Henneke 4
Author
Douglas T. Golenbock 1
Correspondent author
1
Division of Infectious Diseases and Immunology (Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605 - United States)
- UMASS - University of Massachusetts Medical School [Worcester] (55 Lake Avenue North
Worcester, Massachusetts 01655 - United States)
- UMASS - University of Massachusetts System (United States)
2
Laboratório de Inflamação e Imunidade (Rio de Janeiro - Brazil)
- UFRJ - Universidade Federal do Rio de Janeiro (Av. Pedro Calmon, 550 - Cidade Universitária, Rio de Janeiro - RJ, 21941-901 - Brazil)
3
Biologie des Bactéries pathogènes à Gram-positif (Département Microbiologie - 25-28 rue du Dr Roux 75724 Paris cedex 15 - France)
- CNRS - Centre National de la Recherche Scientifique : ERL3526 (France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
Abstract : The inflammatory cytokine IL-1β is critical for host responses against many human pathogens. Here, we define Group B Streptococcus (GBS)-mediated activation of the Nod-like receptor-P3 (NLRP3) inflammasome in macrophages. NLRP3 activation requires GBS expression of the cytolytic toxin, β-hemolysin, lysosomal acidification, and leakage. These processes allow the interaction of GBS RNA with cytosolic NLRP3. The present study supports a model in which GBS RNA, along with lysosomal components including cathepsins, leaks out of lysosomes and interacts with NLRP3 to induce IL-1β production.
Document type :
Journal articles
Complete list of metadata
https://hal-pasteur.archives-ouvertes.fr/pasteur-01299773
Contributor : Anne Lassailly-Bondaz Connect in order to contact the contributor
Submitted on : Friday, April 8, 2016 - 12:26:57 PM
Last modification on : Thursday, December 2, 2021 - 4:12:03 PM
Contributor : Anne Lassailly-Bondaz Connect in order to contact the contributor
Submitted on : Friday, April 8, 2016 - 12:26:57 PM
Last modification on : Thursday, December 2, 2021 - 4:12:03 PM
Links full text
Identifiers
- HAL Id : pasteur-01299773, version 1
- DOI : 10.1074/jbc.C114.548982
- PUBMED : 24692555
- PUBMEDCENTRAL : PMC4022842
Citation
Rahul Gupta, Shubhendu Ghosh, Brian Monks, Rosane B. Deoliveira, Te-Chen Tzeng, et al.. RNA and beta-Hemolysin of Group B Streptococcus Induce Interleukin-1 beta ( IL-1 beta) by Activating NLRP3 Inflammasomes in Mouse Macrophages. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2014, 289 (20), pp.13701-13705. ⟨10.1074/jbc.C114.548982⟩. ⟨pasteur-01299773⟩
Metrics
Les métriques sont temporairement indisponibles